2-(2-Chloroethoxy)ethanol

Synonym(s):Diethylene glycol monochlorohydrin

CAS NO.：628-89-7
Empirical Formula: C4H9ClO2
Molecular Weight: 124.57
MDL number: MFCD00002870
EINECS: 211-059-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

What is 2-(2-Chloroethoxy)ethanol?

Chemical properties

colourless liquid

The Uses of 2-(2-Chloroethoxy)ethanol

2-(2-Chloroethoxy)ethanol is a degradation product of Bis(2-Chloroethyl) Ether. 2-(2-Chloroethoxy)ethanol is a potential genotoxic impurity (PGI) in active pharmaceutical ingredients (APIs).

The Uses of 2-(2-Chloroethoxy)ethanol

2-(2-Chloroethoxy)ethanol is employed in the preparation of o-nitrophenylbromoacetaldehyde bis-2-(2-chloroethoxy)-ethyl acetal, quetiapine and 2-(2-azidoethoxy)ethanol.

The Uses of 2-(2-Chloroethoxy)ethanol

2-(2-Chloroethoxy)ethanol was used in the synthesis of o-nitrophenylbromoacetaldehyde bis-2-(2-chloroethoxy)-ethyl acetal, quetiapine (an antipsychotic drug) and 2-(2-azidoethoxy)ethanol.

Flammability and Explosibility

Non flammable

Properties of 2-(2-Chloroethoxy)ethanol

Boiling point:	79-81 °C5 mm Hg(lit.)
Density	1.18 g/mL at 25 °C(lit.)
vapor pressure	22.66Pa at 20℃
refractive index	n20/D 1.452(lit.)
Flash point:	195 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	SOLUBLE
form	Liquid
pka	14.34±0.10(Predicted)
color	Clear
Water Solubility	SOLUBLE
BRN	506015
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	628-89-7(CAS DataBase Reference)
NIST Chemistry Reference	Ethanol, 2-(2-chloroethoxy)-(628-89-7)
EPA Substance Registry System	Ethanol, 2-(2-chloroethoxy)- (628-89-7)

Safety information for 2-(2-Chloroethoxy)ethanol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.