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HomeProduct name list2-(2-Chloroethoxy)ethanol

2-(2-Chloroethoxy)ethanol

Synonym(s):Diethylene glycol monochlorohydrin

  • CAS NO.:628-89-7
  • Empirical Formula: C4H9ClO2
  • Molecular Weight: 124.57
  • MDL number: MFCD00002870
  • EINECS: 211-059-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2025-01-27 09:38:02
2-(2-Chloroethoxy)ethanol Structural

What is 2-(2-Chloroethoxy)ethanol?

Chemical properties

colourless liquid

The Uses of 2-(2-Chloroethoxy)ethanol

2-(2-Chloroethoxy)ethanol is a degradation product of Bis(2-Chloroethyl) Ether. 2-(2-Chloroethoxy)ethanol is a potential genotoxic impurity (PGI) in active pharmaceutical ingredients (APIs).

The Uses of 2-(2-Chloroethoxy)ethanol

2-(2-Chloroethoxy)ethanol is employed in the preparation of o-nitrophenylbromoacetaldehyde bis-2-(2-chloroethoxy)-ethyl acetal, quetiapine and 2-(2-azidoethoxy)ethanol.

The Uses of 2-(2-Chloroethoxy)ethanol

2-(2-Chloroethoxy)ethanol was used in the synthesis of o-nitrophenylbromoacetaldehyde bis-2-(2-chloroethoxy)-ethyl acetal, quetiapine (an antipsychotic drug) and 2-(2-azidoethoxy)ethanol.

Flammability and Explosibility

Non flammable

Properties of 2-(2-Chloroethoxy)ethanol

Boiling point: 79-81 °C5 mm Hg(lit.)
Density  1.18 g/mL at 25 °C(lit.)
vapor pressure  22.66Pa at 20℃
refractive index  n20/D 1.452(lit.)
Flash point: 195 °F
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  SOLUBLE
form  Liquid
pka 14.34±0.10(Predicted)
color  Clear
Water Solubility  SOLUBLE
BRN  506015
Stability: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 628-89-7(CAS DataBase Reference)
NIST Chemistry Reference Ethanol, 2-(2-chloroethoxy)-(628-89-7)
EPA Substance Registry System Ethanol, 2-(2-chloroethoxy)- (628-89-7)

Safety information for 2-(2-Chloroethoxy)ethanol

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H318:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-(2-Chloroethoxy)ethanol

InChIKey LECMBPWEOVZHKN-UHFFFAOYSA-N

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