(1R)-3-Chloro-1-phenyl-propan-1-ol

Synonym(s):α-(2-Chloroethyl)benzyl alcohol;(R)-(+)-α-(2-Chloroethyl)benzyl alcohol;(R)-(+)-3-Chloro-1-phenylpropanol

CAS NO.：100306-33-0
Empirical Formula: C9H11ClO
Molecular Weight: 170.64
MDL number: MFCD00075128
EINECS: 627-168-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-15 19:00:21

(1R)-3-Chloro-1-phenyl-propan-1-ol Structural

What is (1R)-3-Chloro-1-phenyl-propan-1-ol?

Chemical properties

Off-white Cryst

The Uses of (1R)-3-Chloro-1-phenyl-propan-1-ol

Intermediate in the preparation of (S)-Norfluoxetine

The Uses of (1R)-3-Chloro-1-phenyl-propan-1-ol

(R)-(+)-3-Chloro-1-phenyl-1-propanol may be used as a building block in the synthesis of antidepressants such as (R)- and (S)-tomoxetine, fluoxetine and nisoxetine. It may also be used in the synthesis of biologically active 2-substituted chromans such as tephrowatsin E.

Properties of (1R)-3-Chloro-1-phenyl-propan-1-ol

Melting point:	58-60 °C (lit.)
Boiling point:	296.4±20.0 °C(Predicted)
alpha	26 º (c=1, chloroform)
Density	1.149±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Powder
pka	13.92±0.20(Predicted)
color	White to yellow
optical activity	[α]24/D +26°, c = 1 in chloroform
BRN	5250766
CAS DataBase Reference	100306-33-0(CAS DataBase Reference)

Safety information for (1R)-3-Chloro-1-phenyl-propan-1-ol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.