1,4-Dichlorophthalazine

CAS NO.：4752-10-7
Empirical Formula: C8H4Cl2N2
Molecular Weight: 199.04
MDL number: MFCD00006909
EINECS: 225-275-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-15 16:24:08

What is 1,4-Dichlorophthalazine?

The Uses of 1,4-Dichlorophthalazine

1,4-Dichlorophthalazine Oftens used building block in medicinal chemistry synthesis.1,2

The Uses of 1,4-Dichlorophthalazine

1,4-Dichlorophthalazine was used as starting reagent in the synthesis of series of 4-aryl-1-(4-methylpiperazin-1-yl)phthalazines. It was used as coupling reagent in the synthesis of novel soluble polymer-bound ligand. It was often used as building block in medicinal chemistry synthesis.

Synthesis Reference(s)

Canadian Journal of Chemistry, 43, p. 2708, 1965 DOI: 10.1139/v65-379

Properties of 1,4-Dichlorophthalazine

Melting point:	160-162 °C (lit.)
Boiling point:	397.3±22.0 °C(Predicted)
Density	1.486±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Chloroform, Methanol
form	Powder or Crystalline Powder
pka	-0.44±0.30(Predicted)
color	White to yellow
Water Solubility	Sparingly soluble in water.(0.26 g/L) (25°C),
Sensitive	Moisture Sensitive
CAS DataBase Reference	4752-10-7(CAS DataBase Reference)

Safety information for 1,4-Dichlorophthalazine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.