1,2-Benzisothiazol-3(2H)-one
Synonym(s):1-[2-(N,N-Diethylamino)ethyl]-2-(4-ethoxybenzyl)benzimidazole-5-isothiocyanate;Etonitazenyl isothiocyanate
- CAS NO.:2634-33-5
- Empirical Formula: C7H5NOS
- Molecular Weight: 151.19
- MDL number: MFCD00044001
- EINECS: 220-120-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is 1,2-Benzisothiazol-3(2H)-one?
Description
BIT is an irritant and also a skin sensitizer. Occupational allergie contact dermatitis has been reported mainly related to the use of cutting oils and greases in paint manufacturers, pottery mouldmakers, acrylic emulsion manufacturers, plumbers, printers and lithoprinters, paper makers, an analyticallaboratory, a rubber factory, and in employees manufacturing air fresheners.
Chemical properties
Yellow Powder
The Uses of 1,2-Benzisothiazol-3(2H)-one
Isothiazolinone BIT is widely used in industry as a preservative in water-based solutions, such as pastes, paints and cutting oils. It exists at different concentrations in the different Proxel AB, GXL, CRL, XL2, XL, HL, TN, and in Mergal K-10.
The Uses of 1,2-Benzisothiazol-3(2H)-one
Antimicrobial agent.
What are the applications of Application
1,2-benzisothiazol-3(2H)-one (BIT) has been widely used in high concentrations for microbial growth control in many domestic and industrial processes, its potential eco-risk should be assessed.
Definition
ChEBI: Benzo[d]isothiazol-3-one is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion. It has a role as a disinfectant, a platelet aggregation inhibitor, an environmental contaminant, a xenobiotic, a drug allergen and a sensitiser. It is an organonitrogen heterocyclic compound and an organic heterobicyclic compound.
General Description
1,2-Benzisothiazol-3(2H)-one is a commonly used biocide in industrial and consumer products, which possesses antimicrobial activity against gram positive and gram negative bacteria. It is mainly used in packaging, adhesives, detergents, disinfectants, sunscreen lotions, paints and lubricants.
Flammability and Explosibility
Not classified
Contact allergens
1,2-Benzisothiazol-3(2H)-one, both an irritant and a skin sensitizer, is widely used in industry as a preservative in water-based solutions such as pastes, paints, and cutting oils. Occupational dermatitis has been reported mainly due to cutting fluids and greases, in paint manufacturers, pottery moldmakers, acrylic emulsions manufacturers, plumber,printers and lithoprinters, paper makers, analytical laboratory, rubber factory, and employees manufacturing air fresheners. It is also a preservative in vinyl gloves.
Safety Profile
Moderately toxic by ingestion.When heated to decomposition it emits toxic vapors ofNOx and SOx.
Toxicity evaluation
Isothiazolinones, such as 1,2-benzisothiazol-3(2H)-one (BIT), are widely used as biocides for bacterial growth control in many domestic and industrial processes. Despite their advantages as biocides, they are highly toxic and pose a potential risk to the environment. BIT could seriously inhibit the growth of Scenedesmus sp. LX1, Chlorella sp. HQ, and Chlamydomonas reinhardtii with half maximal effective concentrations at 72 h (72h-EC50) of 1.70, 0.41, and 1.16 mg/L, respectively. The primary inhibition mechanism was the BIT-induced damage to microalgal photosynthetic systems.
Properties of 1,2-Benzisothiazol-3(2H)-one
Melting point: | 154-158 °C(lit.) |
Boiling point: | 360°C (rough estimate) |
Density | 1.2170 (rough estimate) |
vapor pressure | 0Pa at 25℃ |
refractive index | 1.5500 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Soluble in dichloromethane, dimethyl sulfoxide, methanol. |
form | neat |
pka | 10.19±0.20(Predicted) |
form | Solid |
color | White to Light yellow to Light orange |
Water Solubility | 1.288g/L at 20℃ |
CAS DataBase Reference | 2634-33-5 |
EPA Substance Registry System | 1,2-Benzisothiazolin-3-one (2634-33-5) |
Safety information for 1,2-Benzisothiazol-3(2H)-one
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Environment GHS09 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H400:Hazardous to the aquatic environment, acute hazard |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1,2-Benzisothiazol-3(2H)-one
InChIKey | DMSMPAJRVJJAGA-UHFFFAOYSA-N |
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