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HomeProduct name list(±)11(12)-EET

(±)11(12)-EET

  • CAS NO.:123931-40-8
  • Empirical Formula: C20H32O3
  • Molecular Weight: 320.47
  • MDL number: MFCD00132914
  • EINECS: 200-578-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-02 08:55:03
(±)11(12)-EET Structural

What is (±)11(12)-EET?

Description

(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET. 11(12)-EET has been shown, along with 8(9)-EET , to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells. It also inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct when used at a concentration of 100 nM. 11(12)-EET (50 μg/kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation. It also has anti-inflammatory, angiogenic, and cardioprotective properties.

The Uses of (±)11(12)-EET

14(15)-Epoxy-5Z,8Z,11Z-eicosatrienoic Acid-D11 is a deuterium labelled 14(15)-Epoxy-5Z,8Z,11Z-eicosatrienoic Acid (E350670), which is a useful research chemical that acts as an endothelium-derived hyperpolarizing factor in bovine coronary arteries to mediate vascular effects of vasoactive hormones.

Properties of (±)11(12)-EET

Boiling point: 461.8±33.0 °C(Predicted)
Density  0.983±0.06 g/cm3(Predicted)
Flash point: 9℃
storage temp.  -20°C
solubility  DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml
form  Liquid
pka 4.75±0.10(Predicted)
color  Colorless to light yellow

Safety information for (±)11(12)-EET

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H225:Flammable liquids
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for (±)11(12)-EET

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