1-Methylindole-2-carboxylic acid

Synonym(s):NSC 68357

CAS NO.：16136-58-6
Empirical Formula: C10H9NO2
Molecular Weight: 175.18
MDL number: MFCD00005801
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:37

1-Methylindole-2-carboxylic acid Structural

What is 1-Methylindole-2-carboxylic acid?

Chemical properties

Beige crystalline powder

The Uses of 1-Methylindole-2-carboxylic acid

• ;Reactant for preparation of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors1• ;Reactant for synthesis of fenbufen and ethacrynic acid derivatives as potential antitumor agents via amide coupling reactions2• ;Reactant for diastereoselective synthesis of vinylated heterocycles via ruthenium-catalyzed oxidative vinylation with alkenes3• ;Reactant for synthesis of 2,3-dihalo indoles via hypervalent iodine mediated decarboxylative halogenation4• ;Reactant for preparation of α-ketoamides as cathepsin S inhibitors with potential applications ag

The Uses of 1-Methylindole-2-carboxylic acid

Reactant for preparation of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors
Reactant for synthesis of fenbufen and ethacrynic acid derivatives as potential antitumor agents via amide coupling reactions
Reactant for diastereoselective synthesis of vinylated heterocycles via ruthenium-catalyzed oxidative vinylation with alkenes
Reactant for synthesis of 2,3-dihalo indoles via hypervalent iodine mediated decarboxylative halogenation
Reactant for preparation of α-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis
Reactant for preparation of anthranilic acid mimics as bacterial translation inhibitors

What are the applications of Application

1-Methylindole-2-carboxylic acid is a building block used as a reactant in synthesis

General Description

1-Methylindole-2-carboxylic acid reacts with thionyl chloride to yield sulfinyl chlorides.

Properties of 1-Methylindole-2-carboxylic acid

Melting point:	212-213 °C (dec.) (lit.)
Boiling point:	389.0±15.0 °C(Predicted)
Density	1.24±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Crystalline Powder
pka	4.19±0.30(Predicted)
color	Beige
CAS DataBase Reference	16136-58-6(CAS DataBase Reference)
NIST Chemistry Reference	1-Methylindole-2-carboxylic acid(16136-58-6)

Safety information for 1-Methylindole-2-carboxylic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.