1-Methyl-3-pyrrolidinol
- CAS NO.:13220-33-2
- Empirical Formula: C5H11NO
- Molecular Weight: 101.15
- MDL number: MFCD00003176
- EINECS: 236-189-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-24 19:16:04
What is 1-Methyl-3-pyrrolidinol?
Chemical properties
Clear colorless to pale yellow liquid
The Uses of 1-Methyl-3-pyrrolidinol
1-Methyl-3-pyrrolidinol (cas# 13220-33-2) is a compound useful in organic synthesis.
Synthesis
A 500 mL four-necked flask was charged with a 40 wt% aqueous solution of monomethylamine and cooled to 10 ° C in an ice-water bath. Then, while stirring, 1,4-dichloro-2-butanol was added dropwise, and the temperature was controlled at 15 ° C. Then pour the system into an Autoclave, sealed, evacuated to a pressure of 1.0 ± 0.1MPa, while heated to 120 ℃, the reaction was stirred for about 10h. After the reaction was over and cooled to room temperature, the material was discharged, batch-wise added sodium hydroxide was released, and a large amount of methylamine gas, controlling the temperature below 50 ℃, precipitated a lot of white solid, stirred for 1h; filtration, the filtrate layered, the upper organic phase Ethanol And anhydrous magnesium sulfate, stirring 2 ~ 3h; and then filtered, the filtrate was concentrated in vacuo to give a yellow transparent oily liquid, and then vacuum distillation to give colorless and t1-Methyl-3-pyrrolidinol, Yield 64.8%, purity 99.3%.
Properties of 1-Methyl-3-pyrrolidinol
Boiling point: | 50-52 °C1 mm Hg(lit.) |
Density | 0.921 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | 159 °F |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Oil |
pka | 14.95±0.20(Predicted) |
color | Colourless |
InChI | InChI=1S/C5H11NO/c1-6-3-2-5(7)4-6/h5,7H,2-4H2,1H3 |
CAS DataBase Reference | 13220-33-2(CAS DataBase Reference) |
NIST Chemistry Reference | 1-Methyl-3-pyrrolidinol(13220-33-2) |
Safety information for 1-Methyl-3-pyrrolidinol
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 1-Methyl-3-pyrrolidinol
InChIKey | FLVFPAIGVBQGET-UHFFFAOYSA-N |
SMILES | N1(C)CCC(O)C1 |
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