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HomeProduct name list1-Methyl-3-pyrrolidinol

1-Methyl-3-pyrrolidinol

  • CAS NO.:13220-33-2
  • Empirical Formula: C5H11NO
  • Molecular Weight: 101.15
  • MDL number: MFCD00003176
  • EINECS: 236-189-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-04-24 19:16:04
1-Methyl-3-pyrrolidinol Structural

What is 1-Methyl-3-pyrrolidinol?

Chemical properties

Clear colorless to pale yellow liquid

The Uses of 1-Methyl-3-pyrrolidinol

1-Methyl-3-pyrrolidinol (cas# 13220-33-2) is a compound useful in organic synthesis.

Synthesis

A 500 mL four-necked flask was charged with a 40 wt% aqueous solution of monomethylamine and cooled to 10 ° C in an ice-water bath. Then, while stirring, 1,4-dichloro-2-butanol was added dropwise, and the temperature was controlled at 15 ° C. Then pour the system into an Autoclave, sealed, evacuated to a pressure of 1.0 ± 0.1MPa, while heated to 120 ℃, the reaction was stirred for about 10h. After the reaction was over and cooled to room temperature, the material was discharged, batch-wise added sodium hydroxide was released, and a large amount of methylamine gas, controlling the temperature below 50 ℃, precipitated a lot of white solid, stirred for 1h; filtration, the filtrate layered, the upper organic phase Ethanol And anhydrous magnesium sulfate, stirring 2 ~ 3h; and then filtered, the filtrate was concentrated in vacuo to give a yellow transparent oily liquid, and then vacuum distillation to give colorless and t1-Methyl-3-pyrrolidinol, Yield 64.8%, purity 99.3%. 1-Methyl-3-pyrrolidinol

Properties of 1-Methyl-3-pyrrolidinol

Boiling point: 50-52 °C1 mm Hg(lit.)
Density  0.921 g/mL at 25 °C(lit.)
refractive index  n20/D 1.464(lit.)
Flash point: 159 °F
storage temp.  2-8°C
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Oil
pka 14.95±0.20(Predicted)
color  Colourless
InChI InChI=1S/C5H11NO/c1-6-3-2-5(7)4-6/h5,7H,2-4H2,1H3
CAS DataBase Reference 13220-33-2(CAS DataBase Reference)
NIST Chemistry Reference 1-Methyl-3-pyrrolidinol(13220-33-2)

Safety information for 1-Methyl-3-pyrrolidinol

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H227:Flammable liquids
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for 1-Methyl-3-pyrrolidinol

InChIKey FLVFPAIGVBQGET-UHFFFAOYSA-N
SMILES N1(C)CCC(O)C1

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