1-Ethylpiperidine

Synonym(s):N-Ethylpiperidine;NSC 2090

CAS NO.：766-09-6
Empirical Formula: C7H15N
Molecular Weight: 113.2
MDL number: MFCD00006507
EINECS: 212-161-6
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-04 17:34:42

What is 1-Ethylpiperidine?

Chemical properties

CLEAR COLOURLESS TO SLIGHTLY YELLOWISH LIQUID

The Uses of 1-Ethylpiperidine

In Room temperature phosphorescence of α-bromonaphthalene induced by cyclodextrin in the presence of hexahydropyridine or 1-ethylpiperidine and its application is described. The highest yields of 5-Bromopyrimidine (37%) were obtained by using 1-ethylpiperidine or triethylamine as condensing agent. Tributyltin hydride and 1-ethylpiperidine hypophosphite were mediated intermolecular radical additions to 2, 4, 6-trichlorophenyl vinyl sulfonate.

The Uses of 1-Ethylpiperidine

Reactant for: Synthesis of multiprotected kanosamine1 Selective acylation in peptide synthesis2Reagent for: Stereoselective aldol condensation reactions for synthesis of β-lactam antibiotics3 Diastereoselective synthesis of aldols4 Crossed Claisen ester condensation5

Definition

ChEBI: N-ethylpiperidine is a member of piperidines.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 5, p. 575, 1973
The Journal of Organic Chemistry, 28, p. 3259, 1963 DOI: 10.1021/jo01046a537

General Description

A colorless liquid with the odor of pepper. Less dense than water. Flash point 66°F. May irritate skin and eyes. Vapors heavier than air. Used as a solvent and to make other chemicals.

Air & Water Reactions

Highly flammable. Soluble in water.

Reactivity Profile

1-Ethylpiperidine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Highly flammable

Safety Profile

Poison by intravenous and subcutaneous routes. An eye irritant. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits toxic fumes of Nox.

Properties of 1-Ethylpiperidine

Melting point:	-20 °C
Boiling point:	131 °C(lit.)
Density	0.824 g/mL at 25 °C(lit.)
vapor pressure	12.76hPa at 20℃
refractive index	n20/D 1.444(lit.)
Flash point:	66 °F
storage temp.	Flammables area
solubility	1-ethylpiperidine salt of benzylpenicillin is considerably less soluble in amyl acetate and acetone.
form	Liquid
pka	10.45(at 23℃)
color	Clear colorless to slightly yellow
PH	12.2 (50g/l, H2O, 20℃)
explosive limit	1.9-12.1%(V)
Water Solubility	50 G/L
BRN	102643
CAS DataBase Reference	766-09-6(CAS DataBase Reference)
NIST Chemistry Reference	Piperidine, 1-ethyl-(766-09-6)
EPA Substance Registry System	Piperidine, 1-ethyl- (766-09-6)

Safety information for 1-Ethylpiperidine

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H225:Flammable liquids H312:Acute toxicity,dermal H314:Skin corrosion/irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.