1-Chloroisoquinoline

CAS NO.：19493-44-8
Empirical Formula: C9H6ClN
Molecular Weight: 163.6
MDL number: MFCD00024134
EINECS: 628-561-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-02-19 12:30:55

What is 1-Chloroisoquinoline?

Chemical properties

white to yellow low melting solid, crystals and/or

The Uses of 1-Chloroisoquinoline

Used in a Mn-catalyzed cross-coupling with aryl- and alkylmagnesium halides.1 Also used in a Pd-catalyzed cross-coupling with heteroaryl boronic acids and esters.2

The Uses of 1-Chloroisoquinoline

1-Chloroisoquinone is used in the preparation of new aminoisoquinolinylurea derivatives which show antiproliferative activity against melanoma cell lines. It can also be applied to the control of stor age and stability of unstable boronic acids.

The Uses of 1-Chloroisoquinoline

The product has been used in a Mn-catalyzed cross-coupling with aryl- and alkylmagnesium halides. It has also been used in a Pd-catalyzed cross-coupling with heteroaryl boronic acids and esters. Furthermore, it has been used in a homocoupling reaction to yield bis-isoquinoline, each enantiomer of which might be very useful as a chiral ligand for asymmetric synthesis. 1-Chloroisoquinone is used in the preparation of new aminoisoquinolinylurea derivatives which show antiproliferative activity against melanoma cell lines. It can also be applied to the control of storage age and stability of unstable boronic acids.

Properties of 1-Chloroisoquinoline

Melting point:	31-36 °C (lit.)
Boiling point:	274-275 °C/768 mmHg (lit.)
Density	1.2108 (rough estimate)
refractive index	1.6342 (estimate)
Flash point:	>230 °F
storage temp.	Inert atmosphere,2-8°C
form	Low Melting Solid, Crystals and/or Chunks
pka	2.03±0.30(Predicted)
color	White to yellow
Water Solubility	Insoluble in water.
BRN	2996
CAS DataBase Reference	19493-44-8(CAS DataBase Reference)

Safety information for 1-Chloroisoquinoline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.