1,3-Dichloroisoquinoline

CAS NO.：7742-73-6
Empirical Formula: C9H5Cl2N
Molecular Weight: 198.05
MDL number: MFCD00034750
EINECS: 627-814-4
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is 1,3-Dichloroisoquinoline?

Chemical properties

White to brown crystalline powder

The Uses of 1,3-Dichloroisoquinoline

1,3-Dichloroisoquinoline may be used in the facile synthesis of 1,3,4-trisubstituted isoquinoline derivatives.

Synthesis Reference(s)

Journal of the American Chemical Society, 80, p. 5481, 1958 DOI: 10.1021/ja01553a042

General Description

1,3-Dichloroisoquinoline undergoes Pd(PPh₃)₄ catalyzed regioselective coupling with arylboronic acids to afford to 1-aryl-3-chloroisoquinolines. Reaction of amine with 1,3-dichloroisoquinoline has been studied. Regioselectivity of the Stille coupling reaction of (1-ethoxyvinyl)tri(n-butyl)stannane with 1,3-dichloroisoquinoline has been investigated.

Properties of 1,3-Dichloroisoquinoline

Melting point:	121-122 °C (lit.)
Boiling point:	307°C(lit.)
Density	1.407±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
form	powder to crystal
pka	-1.49±0.50(Predicted)
color	Light yellow to Brown to Dark green
CAS DataBase Reference	7742-73-6(CAS DataBase Reference)

Safety information for 1,3-Dichloroisoquinoline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.