1-[(4-Methylphenyl)sulfonyl]-1H-imidazole
Synonym(s):1-Tosylimidazole
- CAS NO.：2232-08-8
- Empirical Formula: C10H10N2O2S
- Molecular Weight: 222.26
- MDL number: MFCD00005285
- EINECS: 218-771-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-23 18:01:39
![1-[(4-Methylphenyl)sulfonyl]-1H-imidazole Structural](https://img.chemicalbook.in/CAS/GIF/2232-08-8.gif)
What is 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole?
Chemical properties
white to slightly yellow crystals
The Uses of 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole
Alcohols to azides in one step.1
The Uses of 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole
1-(p-Toluenesulfonyl)imidazole was used in the synthesis of cationic water soluble cyclodextrin, mono-6A-(1-butyl-3-imidazolium)-6A-deoxy-β-cyclodextrin chloride (BIMCD), useful in chiral separation of amino acids and anionic pharmaceuticals by capillary electrophoresis.
Synthesis Reference(s)
The Journal of Organic Chemistry, 45, p. 547, 1980 DOI: 10.1021/jo01291a044
General Description
1-(p-Toluenesulfonyl)imidazole converts alcohols to azides in one step.
Properties of 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole
| Melting point: | 76-78 °C(lit.) |
| Boiling point: | 409.1±38.0 °C(Predicted) |
| Density | 1.3038 (rough estimate) |
| refractive index | 1.5650 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | chloroform: soluble25mg/mL, clear, colorless to faintly yellow |
| form | Crystals or Crystalline Powder |
| pka | 1.22±0.10(Predicted) |
| color | White to slightly yellow |
| Sensitive | Moisture Sensitive |
| BRN | 612451 |
| CAS DataBase Reference | 2232-08-8(CAS DataBase Reference) |
Safety information for 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole
| InChIKey | YJYMYJRAQYREBT-UHFFFAOYSA-N |
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