1-(2-THIAZOLYLAZO)-2-NAPHTHOL

Synonym(s):2-(2-Hydroxy-1-naphthylazo)thiazole;TAN

CAS NO.：1147-56-4
Empirical Formula: C13H9N3OS
Molecular Weight: 255.3
MDL number: MFCD00021611
EINECS: 214-555-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-04 20:04:50

1-(2-THIAZOLYLAZO)-2-NAPHTHOL Structural

What is 1-(2-THIAZOLYLAZO)-2-NAPHTHOL?

Description

ERGi-USU (1147-56-4) selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or endothelial cells (IC50 = 169 nM for cell growth and 315 nM for ERG protein in VCaP cells). It selectively inhibits the kinase RIOK2 (Kd = 200 nM) causing disruption of ribosomal biogenesis and ribosomal stress.

The Uses of 1-(2-THIAZOLYLAZO)-2-NAPHTHOL

1-(2-Thiazolylazo)-2-naphthol is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.

storage

Store at +4°C

References

1) Mohamed et al. (2018), Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth; Cancer Res. 78 3659

Properties of 1-(2-THIAZOLYLAZO)-2-NAPHTHOL

Melting point:	138-139 °C
Boiling point:	464.8±47.0 °C(Predicted)
Density	1.40
storage temp.	2-8°C
solubility	methanol: 10 mg/mL, clear
form	solid
pka	8.71±0.50(Predicted)
color	Red or orange
BRN	223783
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS DataBase Reference	1147-56-4(CAS DataBase Reference)
EPA Substance Registry System	2-Naphthalenol, 1-(2-thiazolylazo)- (1147-56-4)

Safety information for 1-(2-THIAZOLYLAZO)-2-NAPHTHOL

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.