1-(2-THIAZOLYLAZO)-2-NAPHTHOL
Synonym(s):2-(2-Hydroxy-1-naphthylazo)thiazole;TAN
- CAS NO.：1147-56-4
- Empirical Formula: C13H9N3OS
- Molecular Weight: 255.3
- MDL number: MFCD00021611
- EINECS: 214-555-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:07:02
What is 1-(2-THIAZOLYLAZO)-2-NAPHTHOL?
Description
ERGi-USU (1147-56-4) selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or endothelial cells (IC50 = 169 nM for cell growth and 315 nM for ERG protein in VCaP cells). It selectively inhibits the kinase RIOK2 (Kd = 200 nM) causing disruption of ribosomal biogenesis and ribosomal stress.
The Uses of 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
1-(2-Thiazolylazo)-2-naphthol is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.
storage
Store at +4°C
References
1) Mohamed et al. (2018), Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth; Cancer Res. 78 3659
Properties of 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
| Melting point: | 138-139 °C |
| Boiling point: | 464.8±47.0 °C(Predicted) |
| Density | 1.40 |
| storage temp. | 2-8°C |
| solubility | methanol: 10 mg/mL, clear |
| form | solid |
| pka | 8.71±0.50(Predicted) |
| color | Red or orange |
| BRN | 223783 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| CAS DataBase Reference | 1147-56-4(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Naphthalenol, 1-(2-thiazolylazo)- (1147-56-4) |
Safety information for 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 1-(2-THIAZOLYLAZO)-2-NAPHTHOL
New Products
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