(-)-Epigallocatechin

Synonym(s):(−)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol;(−)-cis-3,3′,4′,5,5′,7-Hexahydroxyflavane;(−)-Epigallocatechin

CAS NO.：970-74-1
Empirical Formula: C15H14O7
Molecular Weight: 306.27
MDL number: MFCD00075939
EINECS: 619-254-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-04 20:04:50

What is (-)-Epigallocatechin?

Chemical properties

white powder

The Uses of (-)-Epigallocatechin

antineoplastic

The Uses of (-)-Epigallocatechin

A natural constituent of green tea. It is an antioxidant and a potential cancer chemopreventive agent. An epimer of (-)-Gallocatechin (G188990).

The Uses of (-)-Epigallocatechin

A natural product from green tea that induces apoptosis

What are the applications of Application

(?)Epigallocatechin is a natural product from green tea shown to inhibit DNA polymerase

Definition

ChEBI: (-)-epigallocatechin is a flavan-3,3',4',5,5',7-hexol having (2R,3R)-configuration. It has a role as an antioxidant, a plant metabolite and a food component. It is a flavan-3,3',4',5,5',7-hexol and a catechin. It is an enantiomer of a (+)-epigallocatechin.

General Description

(?)-Epigallocatechin (EGC) belongs to the tea catechins group of polyphenols.

Biochem/physiol Actions

Green tea polyphenol. Anticancer agent. Lower antioxidant activity than EGCG.

Properties of (-)-Epigallocatechin

Melting point:	208-210°C
alpha	-50 º (c=0.04, EtOH)
Boiling point:	685.6±55.0 °C(Predicted)
Density	1.695±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	9.02±0.15(Predicted)
color	White to Light Beige
λmax	278nm(MeOH)(lit.)
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	970-74-1(CAS DataBase Reference)

Safety information for (-)-Epigallocatechin

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.