(-)-Epigallocatechin
Synonym(s):(−)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol;(−)-cis-3,3′,4′,5,5′,7-Hexahydroxyflavane;(−)-Epigallocatechin
- CAS NO.：970-74-1
- Empirical Formula: C15H14O7
- Molecular Weight: 306.27
- MDL number: MFCD00075939
- EINECS: 619-254-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-01-05 11:48:35
What is (-)-Epigallocatechin?
Chemical properties
white powder
The Uses of (-)-Epigallocatechin
antineoplastic
The Uses of (-)-Epigallocatechin
A natural constituent of green tea. It is an antioxidant and a potential cancer chemopreventive agent. An epimer of (-)-Gallocatechin (G188990).
The Uses of (-)-Epigallocatechin
A natural product from green tea that induces apoptosis
What are the applications of Application
(?)Epigallocatechin is a natural product from green tea shown to inhibit DNA polymerase
Definition
ChEBI: (-)-epigallocatechin is a flavan-3,3',4',5,5',7-hexol having (2R,3R)-configuration. It has a role as an antioxidant, a plant metabolite and a food component. It is a flavan-3,3',4',5,5',7-hexol and a catechin. It is an enantiomer of a (+)-epigallocatechin.
General Description
(?)-Epigallocatechin (EGC) belongs to the tea catechins group of polyphenols.
Biochem/physiol Actions
Green tea polyphenol. Anticancer agent. Lower antioxidant activity than EGCG.
Properties of (-)-Epigallocatechin
| Melting point: | 208-210°C |
| alpha | -50 º (c=0.04, EtOH) |
| Boiling point: | 685.6±55.0 °C(Predicted) |
| Density | 1.695±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Acetone (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.02±0.15(Predicted) |
| color | White to Light Beige |
| λmax | 278nm(MeOH)(lit.) |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 970-74-1(CAS DataBase Reference) |
Safety information for (-)-Epigallocatechin
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (-)-Epigallocatechin
| InChIKey | XMOCLSLCDHWDHP-IUODEOHRSA-N |
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