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204205-90-3

204205-90-3 structural image
Product Name: Indibulin
Formula: C22H16ClN3O2
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COMPUTED DESCRIPTORS

Molecular Weight 389.8 g/mol
XLogP3 3.9
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 5
Exact Mass 389.0931045 g/mol
Monoisotopic Mass 389.0931045 g/mol
Topological Polar Surface Area 64 Ų
Heavy Atom Count 28
Formal Charge 0
Complexity 558
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Indibulin is a synthetic small molecule with antimitotic and potential antineoplastic activities. Indibulin binds to a site on tubulin that is different from taxane- or Vinca alkaloid-binding sites, destabilizing tubulin polymerization and inducing tumor cell cycle arrest and apoptosis. This agent has been shown to be active against multidrug-resistant (MDR) and taxane- resistant tumor cell lines.