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HomeProduct name listZorubicin

Zorubicin

Zorubicin Structural

What is Zorubicin?

Originator

Zorubicin Hydrochloride,ZYF Pharm Chemical

The Uses of Zorubicin

Antineoplastic.

Manufacturing Process

9.024 g daunorubicin-hydrochloride (its preparation and physicochemical properties have been described in British Patent Specification No 985 598) was dissolved in 800 ml ethanol and mixed with 2.5 ml acetic acid and 2.162 g benzoyl hydrazide and heated for 24 hours at 60°C. On cooling the obtained precipitate was filtered off, washed with 100 ml of ethanol and dried in vacuum at 20°C. It was dissolved in water and small quantity of insoluble product was filtered off, the filtrate was lyophilized. (1-(4-((3-Amino-2,3,6- trideoxy-α,L-lyxohexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12- trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide dihydrochloride (zorubicin) was obtained as red-orange crystalline powder; [α] D 20 = -50° (c=0.2 in water). The compound may be employed in the form of different non-toxic salts such as benzoates, fumarates, maleates, tartrates and so on. The best among these compounds proves to be daunorubicin benzoylhydrazone (rubidazone), which is less cardiotoxic (French Pat. No. 1,578,722 published in 1967, Class CO7d).

Therapeutic Function

Antineoplastic, Antileukemic

Properties of Zorubicin

Boiling point: 675.08°C (rough estimate)
Density  1.2920 (rough estimate)
refractive index  1.7800 (estimate)

Safety information for Zorubicin

Computed Descriptors for Zorubicin

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