Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listY-27632 DIHYDROCHLORIDE

Y-27632 DIHYDROCHLORIDE

Synonym(s):(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-Pyridyl)cyclohexanecarboxamide dihydrochloride;(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, ROCK Inhibitor, Rho Kinase Inhibitor VI;ROCK Inhibitor, (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI; - CAS 146986-50-7 - Calbiochem

  • CAS NO.:146986-50-7
  • Empirical Formula: C14H21N3O
  • Molecular Weight: 247.34
  • MDL number: MFCD03490488
  • EINECS: 1312995-182-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-18 19:43:17
Y-27632 DIHYDROCHLORIDE Structural

What is Y-27632 DIHYDROCHLORIDE?

The Uses of Y-27632 DIHYDROCHLORIDE

Y-27632 Dihydrochloride is a salt analog of Y-27632, which is Rho-kinase inhibitor.

What are the applications of Application

Y-27632, free base is the free base form of Y-27632 dihydrochloride and a novel and specific inhibitor of Rho-associated kinases.

Definition

ChEBI: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory acti ity against Rho-associated protein kinase (ROCK) enzyme.

Biological Activity

Selective inhibitor of the Rho-associated protein kinase p160ROCK. K i values are 0.14, 26, 25 and >250 μ M for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2 (IC 50 = 600nM). Smooth muscle relaxant and orally active in vivo . Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation.

References

[1] ishizaki t1, uehata m, tamechika i, keel j, nonomura k, maekawa m, narumiya s. pharmacological properties of y-27632, a specific inhibitor of rho-associated kinases. mol pharmacol. 2000 may;57(5):976-83.

Properties of Y-27632 DIHYDROCHLORIDE

Melting point: >260°C (dec.)
Boiling point: 462.6±15.0 °C(Predicted)
Density  1.136±0.06 g/cm3(Predicted)
storage temp.  Keep in dark place,Sealed in dry,2-8°C
solubility  H2O: 14 mg/mL
form  solid
pka 13.53±0.40(Predicted)
color  white
Stability: Hygroscopic

Safety information for Y-27632 DIHYDROCHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H312:Acute toxicity,dermal
H332:Acute toxicity,inhalation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for Y-27632 DIHYDROCHLORIDE

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.