Y-27632 DIHYDROCHLORIDE
Synonym(s):(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-Pyridyl)cyclohexanecarboxamide dihydrochloride;(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, ROCK Inhibitor, Rho Kinase Inhibitor VI;ROCK Inhibitor, (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI; - CAS 146986-50-7 - Calbiochem
- CAS NO.：146986-50-7
- Empirical Formula: C14H21N3O
- Molecular Weight: 247.34
- MDL number: MFCD03490488
- EINECS: 1312995-182-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:16
What is Y-27632 DIHYDROCHLORIDE?
The Uses of Y-27632 DIHYDROCHLORIDE
Y-27632 Dihydrochloride is a salt analog of Y-27632, which is Rho-kinase inhibitor.
What are the applications of Application
Y-27632, free base is the free base form of Y-27632 dihydrochloride and a novel and specific inhibitor of Rho-associated kinases.
Definition
ChEBI: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory acti ity against Rho-associated protein kinase (ROCK) enzyme.
Biological Activity
Selective inhibitor of the Rho-associated protein kinase p160ROCK. K i values are 0.14, 26, 25 and >250 μ M for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2 (IC 50 = 600nM). Smooth muscle relaxant and orally active in vivo . Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation.
References
[1] ishizaki t1, uehata m, tamechika i, keel j, nonomura k, maekawa m, narumiya s. pharmacological properties of y-27632, a specific inhibitor of rho-associated kinases. mol pharmacol. 2000 may;57(5):976-83.
Properties of Y-27632 DIHYDROCHLORIDE
| Melting point: | >260°C (dec.) |
| Boiling point: | 462.6±15.0 °C(Predicted) |
| Density | 1.136±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | H2O: 14 mg/mL |
| form | solid |
| pka | 13.53±0.40(Predicted) |
| color | white |
| Stability: | Hygroscopic |
Safety information for Y-27632 DIHYDROCHLORIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H332:Acute toxicity,inhalation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Y-27632 DIHYDROCHLORIDE
New Products
Tubulysin H Tubulysin M Tubulysin G (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride 3-N-BOC-(S)-AMINO BUTYRONITRILE 2H-Pyran, 4-ethynyltetrahydro- Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 3-Aminocyclobutanone hydrochloride 4,4-DIFLUOROCYCLOHEXANAMINE tetrahydro-4-methyl-2H-pyran 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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