(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide

CAS NO.：199433-58-4
Empirical Formula: C16H16N4O
Molecular Weight: 280.32
MDL number: MFCD16038858
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:55:13

What is (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide?

Definition

ChEBI: 4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide is a pyrrolopyridine.

Biological Activity

Y-33075 is a potent ROCK inhibitor derived from Y-27632, but more active with IC50 value of 3.6 nM.

in vitro

Y-33075 (Y-39983) is a potent ROCK inhibitor, with an IC ₅₀ of 3.6 nM. It also inhibits PKC and CaMKII more potently than Y-27632, and the IC ₅₀ s of Y-27632 and Y-33075 for PKC are 9.0 μM and 0.42 μM, respectively, whereas the IC ₅₀ s of Y-27632 and Y- 33075 for CaMKII are 26 μM and 0.81 μM, respectively. The IC ₅₀ s of Y-27632 and Y-33075 for PKC are 82 and 117 times those for ROCK, respectively, whereas the IC ₅₀ s of Y-27632 and Y-33075 for CaMKII is 236 and 225 times those for ROCK, respectively. Y-33075 (Y-39983, 10 μM) extends neurites in the retinal ganglion cells (RGCs) compared with those in RGCs treated without Y-39983. It (Y-39983, 1 μM) inhibits the contraction of rabbit ciliary artery segments evoked by histamine in Ca ²⁺ -free solutions. Y-33075 ( 10 μM) shows no effect on the [Ca ²⁺ ]i increase with the high-potassium (high-K) solution.

Properties of (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide

Boiling point:	588.8±50.0 °C(Predicted)
Density	1.32
storage temp.	Store at -20°C
solubility	DMSO : 50 mg/mL (178.37 mM; Need ultrasonic and warming)H2O : < 0.1 mg/mL (insoluble)
form	Powder
pka	11.13±0.20(Predicted)
color	White to off-white

Safety information for (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide

Computed Descriptors for (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide

New Products

Tubulysin I Tubulysin H 2,2-diethoxyethanethioamide Tubulysin G (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate 4,4-DIFLUOROCYCLOHEXANAMINE 1-(1,1-Difluoroethyl)-2-fluorobenzene CYCLOBUTYLAMINE HYDROCHLORIDE 4,4-DIFLUOROPIPERIDINE 2,2-Difluoropropylamine hydrochloride 4-(Benzyloxy)-3-bromophenylacetic Acid (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 1H-Imidazole-4-carbonitrile

Related products of tetrahydrofuran

Y-27632 DIHYDROCHLORIDE

(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride

Y320

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE

Y27632 (hydrochloride)

N-Ethylaniline

PRND