(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride
- CAS NO.:173897-44-4
- Empirical Formula: C16H18Cl2N4O
- Molecular Weight: 353.24632
- MDL number: MFCD00945328
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:06
What is (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride?
The Uses of (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride
Y-39983 Hydrochloride contain Rho kinase inhibitory activity.
Biological Activity
y-39983 dihydrochloride is a novel and selective inhibitor of rock family with ic50 value of 3.6nm for rock [1].y-39983 dihydrochloride has shown a selective inhibitor of rho-associated coiled coil-forming protein kinase( rock ) with ic50 values of 3.6nm, 0.42μm and 0.81μm for rock, pkc and camkii, respectively [1]. apart from these, y-39983 has been reported to relax the ciliary arteries of precontracted isolated rabbit in vitro. in addition, y-39983 has been found to increase optic-nerve-head blood flow by laser speckle flowmetry [2]. moreover, y-39983 lowered the intraocular pressure ( iop) in a dose-dependent fashion in the eyes of rabbits and monkeys [1].
References
[1] tokushige h1, inatani m, nemoto s, sakaki h, katayama k, uehata m, tanihara h. effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. invest ophthalmol vis sci. 2007 jul;48(7):3216-22.
[2] watabe h1, abe s, yoshitomi t. effects of rho-associated protein kinase inhibitors y-27632 and y-39983 on isolated rabbit ciliary arteries. jpn j ophthalmol. 2011 jul;55(4):411-7. doi: 10.1007/s10384-011-0048-9. epub 2011 jun 11.
Properties of (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride
storage temp. | Inert atmosphere,Room Temperature |
solubility | Soluble in DMSO |
form | Solid |
color | White to gray |
Safety information for (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride
Computed Descriptors for (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride
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