WS3
Synonym(s):N-[6-[4-[[[[4-[(4-Methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-cyclopropanecarboxamide;WS-3
- CAS NO.:1421227-52-2
- Empirical Formula: C28H30F3N7O3
- Molecular Weight: 569.58
- MDL number: MFCD26142950
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is WS3?
The Uses of WS3
WS3 is a β-cell proliferation indocer via the IκB kinase pathway and modulation of the Erb3 binding-protein. Potential treatment and cure for diabetes type I.
Biological Activity
ws 3 is an agonist of trpm8 receptor with ec50 value of 3.7 μm [1].transient receptor potential cation channel subfamily m member 8 (trpm8) is a ca2+- and na+-permeable ion channel and is activated by cooling agents and cold temperatures. trpm8 belongs to trp family and is expressed in sensory neurons.ws 3 is an agonist of trpm8 receptor and a cooling agent. in hek293 cells expressed recombinant mouse trpm8, ws 3 (30 μm) increased [ca2+]i. ws 3 exhibited potency with ec50 value of 3.7 μm and induced 86% efficacy of the maximal response to icilin, the most potent agonist [1]. in hek cells stably expressing either htrpm8 or htrpa1, ws 3 activated htrpm8 and htrpa1 with ec50 values of 2.2 and 120.6 μm, respectively. ws 3 was efficacious in eliciting cooling sensation [2].
References
[1]. behrendt hj, germann t, gillen c, et al. characterization of the mouse cold-menthol receptor trpm8 and vanilloid receptor type-1 vr1 using a fluorometric imaging plate reader (flipr) assay. br j pharmacol, 2004, 141(4): 737-745.
[2]. klein ah, iodi carstens m, mccluskey ts, et al. novel menthol-derived cooling compounds activate primary and second-order trigeminal sensory neurons and modulate lingual thermosensitivity. chem senses, 2011, 36(7): 649-658.
Properties of WS3
Boiling point: | 632.9±55.0 °C(Predicted) |
Density | 1.423±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,2-8°C |
solubility | DMSO: soluble10mg/mL, clear |
pka | 11.82±0.20(Predicted) |
form | powder |
color | white to beige |
Safety information for WS3
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H320:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for WS3
New Products
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