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HomeProduct name listWS3

WS3

Synonym(s):N-[6-[4-[[[[4-[(4-Methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-cyclopropanecarboxamide;WS-3

WS3 Structural

What is WS3?

The Uses of WS3

WS3 is a β-cell proliferation indocer via the IκB kinase pathway and modulation of the Erb3 binding-protein. Potential treatment and cure for diabetes type I.

Biological Activity

ws 3 is an agonist of trpm8 receptor with ec50 value of 3.7 μm [1].transient receptor potential cation channel subfamily m member 8 (trpm8) is a ca2+- and na+-permeable ion channel and is activated by cooling agents and cold temperatures. trpm8 belongs to trp family and is expressed in sensory neurons.ws 3 is an agonist of trpm8 receptor and a cooling agent. in hek293 cells expressed recombinant mouse trpm8, ws 3 (30 μm) increased [ca2+]i. ws 3 exhibited potency with ec50 value of 3.7 μm and induced 86% efficacy of the maximal response to icilin, the most potent agonist [1]. in hek cells stably expressing either htrpm8 or htrpa1, ws 3 activated htrpm8 and htrpa1 with ec50 values of 2.2 and 120.6 μm, respectively. ws 3 was efficacious in eliciting cooling sensation [2].

References

[1]. behrendt hj, germann t, gillen c, et al. characterization of the mouse cold-menthol receptor trpm8 and vanilloid receptor type-1 vr1 using a fluorometric imaging plate reader (flipr) assay. br j pharmacol, 2004, 141(4): 737-745.
[2]. klein ah, iodi carstens m, mccluskey ts, et al. novel menthol-derived cooling compounds activate primary and second-order trigeminal sensory neurons and modulate lingual thermosensitivity. chem senses, 2011, 36(7): 649-658.

Properties of WS3

Boiling point: 632.9±55.0 °C(Predicted)
Density  1.423±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,2-8°C
solubility  DMSO: soluble10mg/mL, clear
pka 11.82±0.20(Predicted)
form  powder
color  white to beige

Safety information for WS3

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H320:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P330:Rinse mouth.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Computed Descriptors for WS3

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