WS 12
Synonym(s):(1R,2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboxamide
- CAS NO.:68489-09-8
- Empirical Formula: C18H27NO2
- Molecular Weight: 289.41
- MDL number: MFCD11100191
- EINECS: 700-232-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 18:15:48
What is WS 12?
Description
WS-12 is an agonist of transient receptor potential melastatin 8 (TRPM8). It induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 = 12 μM) and is selective for TRPM8 over transient receptor potential vanilloid 1-4 (TRPV1-4) and transient receptor potential ankyrin 1 (TRPA1) at 1 mM. WS-12 (6 nmol, i.c.v.) reduces nocifensive behavior induced by capsaicin in wild-type, but not Trpm8-/-, mice. It induces analgesia in the hot plate test, an effect that can be reversed by the opioid receptor antagonist naloxone, in mice.
Chemical properties
WS 12 is a odorless white crystalline solid,mp 178 °C, displaying a strong initial cooling effect and a long-lastingness. It is used particularly is oral care flavors.
The Uses of WS 12
WS 12 is a potent TRPM8 agonist.
What are the applications of Application
WS 12 is a synthetic carboxamide and potent, selective TRPM8 channel agonist, activating TRPM8 channels expressed in HEK-293 cells.
Trade name
Winsense WS-12 (Renessenz)
Biological Activity
Potent TRPM8 agonist that acts as a cooling agent (EC 50 = 193 nM).
Biochem/physiol Actions
WS-12 is a menthol derivative, that shows a specific binding affinity towards TRPM8 (transient receptor potential cation channel subfamily M member 8) receptor. TRPM8 is associated with prostate cancer and thus, WS-12 might be useful in reducing the progression of cancer.
storage
Store at -20°C
Properties of WS 12
Boiling point: | 447.8±28.0 °C(Predicted) |
Density | 1.029±0.06 g/cm3(Predicted) |
vapor pressure | 0-0Pa at 20-50℃ |
FEMA | 4681 | (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE |
storage temp. | -20°C |
solubility | DMSO: >20mg/mL |
pka | 14.18±0.70(Predicted) |
form | White to off-white powder. |
color | white to off-white |
Odor | at 100.00 %. cool minty |
JECFA Number | 2079 |
CAS DataBase Reference | 68489-09-8 |
Safety information for WS 12
Signal word | Warning |
Pictogram(s) |
Environment GHS09 |
GHS Hazard Statements |
H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P501:Dispose of contents/container to..… |
Computed Descriptors for WS 12
InChIKey | HNSGVPAAXJJOPQ-XOKHGSTOSA-N |
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