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HomeProduct name listWS 12

WS 12

Synonym(s):(1R,2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboxamide

  • CAS NO.:68489-09-8
  • Empirical Formula: C18H27NO2
  • Molecular Weight: 289.41
  • MDL number: MFCD11100191
  • EINECS: 700-232-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-31 18:15:48
WS 12 Structural

What is WS 12?

Description

WS-12 is an agonist of transient receptor potential melastatin 8 (TRPM8). It induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 = 12 μM) and is selective for TRPM8 over transient receptor potential vanilloid 1-4 (TRPV1-4) and transient receptor potential ankyrin 1 (TRPA1) at 1 mM. WS-12 (6 nmol, i.c.v.) reduces nocifensive behavior induced by capsaicin in wild-type, but not Trpm8-/-, mice. It induces analgesia in the hot plate test, an effect that can be reversed by the opioid receptor antagonist naloxone, in mice.

Chemical properties

WS 12 is a odorless white crystalline solid,mp 178 °C, displaying a strong initial cooling effect and a long-lastingness. It is used particularly is oral care flavors.

The Uses of WS 12

WS 12 is a potent TRPM8 agonist.

What are the applications of Application

WS 12 is a synthetic carboxamide and potent, selective TRPM8 channel agonist, activating TRPM8 channels expressed in HEK-293 cells.

Trade name

Winsense WS-12 (Renessenz)

Biological Activity

Potent TRPM8 agonist that acts as a cooling agent (EC 50 = 193 nM).

Biochem/physiol Actions

WS-12 is a menthol derivative, that shows a specific binding affinity towards TRPM8 (transient receptor potential cation channel subfamily M member 8) receptor. TRPM8 is associated with prostate cancer and thus, WS-12 might be useful in reducing the progression of cancer.

storage

Store at -20°C

Properties of WS 12

Boiling point: 447.8±28.0 °C(Predicted)
Density  1.029±0.06 g/cm3(Predicted)
vapor pressure  0-0Pa at 20-50℃
FEMA  4681 | (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE
storage temp.  -20°C
solubility  DMSO: >20mg/mL
pka 14.18±0.70(Predicted)
form  White to off-white powder.
color  white to off-white
Odor at 100.00 %. cool minty
JECFA Number 2079
CAS DataBase Reference 68489-09-8

Safety information for WS 12

Signal word Warning
Pictogram(s)
ghs
Environment
GHS09
GHS Hazard Statements H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P273:Avoid release to the environment.
P391:Collect spillage. Hazardous to the aquatic environment
P501:Dispose of contents/container to..…

Computed Descriptors for WS 12

InChIKey HNSGVPAAXJJOPQ-XOKHGSTOSA-N

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