VX-222
- CAS NO.：1026785-59-0
- Empirical Formula: C25H35NO4S
- Molecular Weight: 445.61
- MDL number: MFCD18089858
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:02:58
What is VX-222?
Description
Lomibuvir is a non-nucleoside inhibitor of the RNA-directed RNA polymerase of hepatitis C virus (HCV; Ki = 17 nM) that inhibits primer-dependent RNA synthesis selectively over de novo RNA synthesis. It inhibits HCV replication in Huh7.5 cells expressing the 1b/Con1 HCV subgenomic replicon (EC50 = 5 nM).
The Uses of VX-222
VX-222, s a novel, potent and selective inhibitor of HCV polymerase .
Definition
ChEBI: 5-(3,3-dimethylbut-1-ynyl)-3-[(4-hydroxycyclohexyl)-[(4-methylcyclohexyl)-oxomethyl]amino]-2-thiophenecarboxylic acid is a thiophenecarboxylic acid.
Properties of VX-222
| Boiling point: | 640.5±55.0 °C(Predicted) |
| Density | 1.21 |
| storage temp. | Store at -20°C |
| solubility | ≥44.6 mg/mL in DMSO; insoluble in H2O; ≥97.2 mg/mL in EtOH |
| form | solid |
| pka | 3.67±0.10(Predicted) |
Safety information for VX-222
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for VX-222
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