VINYL CHLOROFORMATE

Synonym(s):Vinyl chlorocarbonate;Vinyloxycarbonyl chloride

CAS NO.：5130-24-5
Empirical Formula: C3H3ClO2
Molecular Weight: 106.51
MDL number: MFCD00000641
EINECS: 225-874-2
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is VINYL CHLOROFORMATE?

Chemical properties

clear colourless liquid

The Uses of VINYL CHLOROFORMATE

Vinyl Chloroformate was used to prepare analogues of the Nicotinic Acetylcholine Receptor Agonist (±)-UB-165. It was also used to synthesize possible antitumor agents such as paclitaxel-2''-carbonates and N-carbamyl triazenes.

Purification Methods

It has been fractionated through a Todd column (p 11, Model A with ~60 plates) under atmospheric pressure and the purity can be checked by gas chromatography. Stabilize it with 0.5% of 2,6-di-tert-butyl-p-cresol. It has IR with at 3100 + 2870 (CH2), 1780 (C=O), 1640 (C=C) and 940 (CH2out-of-plane) and 910 (CH2 wagging) cm-1. [IR: Lee J Org Chem 30 3943 1965, Levaillant Ann Chim (Paris) 6 504 1936.] It is used for protecting NH2 groups in peptide synthesis [Olofson et al. Tetrahedron Lett 1563 1977]. [Beilstein 3 III 28.]

Properties of VINYL CHLOROFORMATE

Boiling point:	68-69 °C735 mm Hg(lit.)
Density	1.166 g/mL at 20 °C(lit.)
vapor pressure	0.88 psi ( 20 °C)
refractive index	n20/D 1.41(lit.)
Flash point:	24 °F
storage temp.	2-8°C
form	Liquid
color	Clear colorless
BRN	1741679

Safety information for VINYL CHLOROFORMATE

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H225:Flammable liquids H314:Skin corrosion/irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.