Verdinexor (KPT-335)
- CAS NO.:1392136-43-4
- Empirical Formula: C18H12F6N6O
- Molecular Weight: 442.32
- MDL number: MFCD28167840
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:54:57
What is Verdinexor (KPT-335)?
The Uses of Verdinexor (KPT-335)
Verdinexor is a potent and selective SINE inhibitor, shown to be effective in treating influenza A virus infection in mice and ferret models.
Biological Activity
verdinexor (kpt-335) is a potent and selective inhibitor of nuclear export [1].nuclear export (sine) is mainly mediated by exportin 1 (xpo1) and mediates specific proteins out of the nucleus, which plays an important role in the regulation of proliferation and the cell cycle [2].verdinexor (kpt-335) is a potent and selective sine inhibitor that acts as an antiviral drug. in a549 cells inoculated with the influenza a and b virus, verdinexor effectively inhibited the replication of the influenza a and b virus strains tested. verdinexor (1 μm) caused the accumulation of vrnps in the nuclei and altered the localization of viral ns1. also, verdinexor increased nuclear negative-sense vrna by 56.6-fold and significantly reduced cytoplasmic negative-sense vrna, which suggested that verdinexor blocked vrnp nuclear export. in 293t cells, verdinexor inhibited xpo1-nep binding [1].in mice infected with influenza virus a, verdinexor significantly reduced lung influenza virus a titers. verdinexor also reduced the expression of proinflammatory cytokines tumor necrosis factor alpha, interleukin-6, interleukin-1β and gamma interferon. in mice infected with a lethal dose, verdinexor inhibited virus penetration of the respiratory tract and virus spread in the lungs [1]. in companion dogs with b- and t-cell lymphomas, verdinexor showed potent cytotoxic activity [2].
storage
Store at -20°C
References
[1]. perwitasari o, johnson s, yan x, et al. verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo. j virol, 2014, 88(17): 10228-10243.
[2]. gravina gl, senapedis w, mccauley d, et al. nucleo-cytoplasmic transport as a therapeutic target of cancer. j hematol oncol, 2014, 7: 85.
Properties of Verdinexor (KPT-335)
Density | 1.49±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | ≥44.2 mg/mL in DMSO; insoluble in H2O; ≥2.31 mg/mL in EtOH with ultrasonic |
form | solid |
pka | 10.04±0.43(Predicted) |
color | Light yellow to yellow |
CAS DataBase Reference | 1392136-43-4 |
Safety information for Verdinexor (KPT-335)
Computed Descriptors for Verdinexor (KPT-335)
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