UNC-0642

Synonym(s):2-(4,4-Difluoropiperidin-1-yl)-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine

CAS NO.：1481677-78-4
Empirical Formula: C29H44F2N6O2
Molecular Weight: 546.7
MDL number: MFCD28044322
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-16 15:32:52

What is UNC-0642?

The Uses of UNC-0642

UNC 0642 is an in vivo chemical probe of the lysine methyltransferases G9a and GLP which maintains high in vitro and cellular potency, low cell toxicity, and selectivity.

What are the applications of Application

UNC 0642 is a selective and potent G9a and GLP inhibitor

Biochem/physiol Actions

UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a (EHMT2) and GLP (EHMT1), which catalyze the mono and dimethylation of lysine 9 of histone 3 (H3K9), and other non-histone substrates such as p53 and WIZ. UNC0642 has an in vitro IC50 <15 nM with greater than 100-fold selectivity over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. UNC0642 has the same potency with improved PK properties relative to UNC0638, which should make it a more useful probe in an in vivo setting. For full characterization details, please visit the UNC0642 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

storage

Store at -20°C

Properties of UNC-0642

Boiling point:	679.2±65.0 °C(Predicted)
Density	1.23±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
pka	10.06±0.20(Predicted)
form	powder
color	white to beige

Safety information for UNC-0642

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.