U 18666A
Synonym(s):(3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride;3β-(2-Diethylaminoethoxy)androst-5-en-17-one, HCl;U18666A - CAS 3039-71-2 - Calbiochem
- CAS NO.:3039-71-2
- Empirical Formula: C25H42ClNO2
- Molecular Weight: 424.06
- MDL number: MFCD00210908
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-29 17:14:30
What is U 18666A?
Description
U-18666A (3039-71-2) is an oxidosqualene reductase inhibitor.1 Inhibits the egress of cholesterol from late endosomes and lysosomes.2 U-18666A is also used to study Niemann-Pick disease and for assessing the importance of molecular trafficking through the lysosomal pathway in other conditions.3
The Uses of U 18666A
U 18666A is a cell-permeable amphiphilic amino-steroid.
What are the applications of Application
U 18666A is a cell-permeable amphiphilic amino-steroid
Definition
ChEBI: 3beta-(2-diethylaminoethoxy)androst-5-en-17-one hydrochloride is a hydrochloride obtained by reaction of 3beta-(2-diethylaminoethoxy)androst-5-en-17-one with one equivalent of hydrochloric acid. It is a cholesterol synthesis and transport inhibitor. It has a role as an EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor, a nicotinic antagonist, a sterol biosynthesis inhibitor, an antiviral agent and a Hedgehog signaling pathway inhibitor. It contains a 3beta-(2-diethylaminoethoxy)androst-5-en-17-one(1+).
General Description
A cell-permeable, amphiphilic amino-steroid that alters intracelluar membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol. Reported to exert its effects via the inhibition of 2,3-oxidosqualene-lanosterol cyclase activity. Also reported to inhibit the activity of Δ8-sterol isomerase.
Biological Activity
Inhibitor of cholesterol synthesis and cellular transport, and weak inhibitor of hedgehog (Hh) signaling. Reduces serum sterol levels in rats in vivo .
Biochem/physiol Actions
Cell permeable: yes
storage
Desiccate at RT
References
1) Sexton et al. (1983) Effects of 3.beta.-[2-(diethylamino)ethoxy]androst-5-en-17-one on the synthesis of cholesterol and ubiquinone in rat intestinal epithelial cell cultures; Biochemistry 22 5687 2) Liscum and Faust (1989) The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-?-[2-(diethylamino)ethoxy]androst-5-en-17-one; J. Biol. Chem. 264 11796 3) Cenedella, (2009) Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes; Lipids 44 477
Properties of U 18666A
Melting point: | 195-196.5 °C(lit.) |
storage temp. | 2-8°C |
solubility | H2O: 9 mg/mL at ≤60 °C |
form | crystalline |
color | white |
Water Solubility | Soluble in water at 10mg/ml |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 week. |
Safety information for U 18666A
Computed Descriptors for U 18666A
Abamectin manufacturer
SRI ANAGHA BIOSCIENCES PVT LTD
New Products
(2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride 2,2-diethoxyethanethioamide Tubulysin B Tubulysin E Tubulysin C 4-IODOTETRAHYDRO-2H-PYRAN 2H-Pyran, 4-ethynyltetrahydro- 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-(Benzyloxy)-3-bromophenylacetic Acid Cyclobutanamine, 3,3-difluoro- (9CI) 5-Methyl-1-indanone 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Magnesium Trisilicate Latanoprostene Bunod Lubiprostone Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
You may like
-
3039-71-2 (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride 98%View Details
3039-71-2 -
U 18666a CAS 3039-71-2View Details
3039-71-2 -
U18666A CAS 3039-71-2View Details
3039-71-2 -
(R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateView Details
2416850-45-6 -
methyl 3-fluoro-4- thiomorpholino phenylcarbamateView Details
2760359-22-4 -
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8