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HomeProduct name listTroxerutin

Troxerutin

Synonym(s):3′,4′,7-Tris[O-(2-hydroxyethyl)]rutin;Trihydroxyethylrutin;Troxerutin

  • CAS NO.:7085-55-4
  • Empirical Formula: C33H42O19
  • Molecular Weight: 742.68
  • MDL number: MFCD00893813
  • EINECS: 230-389-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Troxerutin Structural

What is Troxerutin?

Chemical properties

Yellow Powder

Originator

Venoruton,Novartis Co

The Uses of Troxerutin

Troxerutin, a derivative of the naturally occurring bioflavonoid rutin, is thought to inhibit red cell and platelet aggregation, improve erythrocyte deformability, and improve plasma viscosity retinal microcirculation. A double-blind randomized clinical trial compared troxerutin with placebo in 27 patients with CRVO. The limitations of the study included a small number of patients and short follow-up time.

The Uses of Troxerutin

Used in the treatment of venous disorders

The Uses of Troxerutin

vasoprotectant

What are the applications of Application

Trihydroxyethylrutin is a flavonoid derivative which is effective in protecting membranes from oxidative DNA damage.

Manufacturing Process

In a nitrogen atmosphere 120 g of caustic soda (3 moles) in solution are added to 610 g of rutin (1 mol) suspended in 2 litres of water, the mixture being vigorously agitated by a mechanical stirrer, 241.5 g of ethylene chlorohydrin being then introduced at 55°C for 10 min. When all the chlorohydrin has been thus added the temperature is progressively raised to 75°C and maintained at this level for 2 hours. After cooling, in a nitrogen atmosphere, the pH value adjusted to 5 by the addition of dilute hydrochloric acid. The solution is kept in an ice box for 24 hours and then filtered to remove any impurities. At reduced pressure the solution is evaporated until dry, the residue taken up in 3 litres of boning methanol which dissolves the tri-(β-hydroxyethyl)rutin formed and leaves the sparingly soluble sodium chloride behind. The tri-(β-hydroxyethyl)rutin is recovered from its methanolic solution either by evaporation and refrigeration, or by evaporation precipitation with absolute ethanol. In either case tri-(β-hydroxyethyl)rutin obtained is in the form of small very hygroscopic crystals which contain alcohol of crystallization.These crystals are quickly shaken washed in a little cold absolute ethanol and then dried in vacuum at 100°C. 680 g of anhydrous tri-(β-hydroxyethyl)rutin are thus obtained in the form of a yellow powder which melts at 156°C.GB Patent No. 833,174; April 21, 1960; Assigned to Zyma S.A., a Swiss Corporation, of Route Etraz, Nyon Canton of Vaud, Switzerland

Therapeutic Function

Topical venotonic

Properties of Troxerutin

Melting point: 181°C
Boiling point: 1058.4±65.0 °C(Predicted)
Density  1.65±0.1 g/cm3(Predicted)
storage temp.  Sealed in dry,Store in freezer, under -20°C
solubility  Freely soluble in water, slightly soluble in ethanol (96 per cent) and practically insoluble in methylene chloride.
form  neat
pka 5.92±0.40(Predicted)
form  Solid
color  Light Yellow to Yellow
Merck  14,9789
BRN  4778232
CAS DataBase Reference 7085-55-4(CAS DataBase Reference)

Safety information for Troxerutin

Computed Descriptors for Troxerutin

InChIKey KMPBUGGPUQOWMJ-NXPSPVSKSA-N

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