Tropisetron hydrochloride
Synonym(s):1H-Indole-3-carboxylic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester monohydrochloride;3-Tropanylindole-3-carboxylate monohydrochloride;ICS-205,930;Navoban;Tropisetron monohydrochloride
- CAS NO.：105826-92-4
- Empirical Formula: C17H21ClN2O2
- Molecular Weight: 320.81
- MDL number: MFCD02313825
- EINECS: 630-417-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is Tropisetron hydrochloride?
Chemical properties
White to Off-White Crystalline Solid
The Uses of Tropisetron hydrochloride
Specific serotonin (5-HT3) receptor antagonist. Antiemetic.
The Uses of Tropisetron hydrochloride
A selective 5-HT3 serotonin receptor antagonist
What are the applications of Application
Tropisetron hydrochloride is a potent SR-3 antagonist
Definition
ChEBI: A hydrochloride obtained by combining equimolar amounts of tropisetron and hydrogen chloride.
Biological Activity
Potent, orally active 5-HT 3 receptor antagonist. Antiemetic.
Biochem/physiol Actions
Tropisetron a selective serotonin 5-HT3 receptor antagonist is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy . In the treatment of fibromyalgia syndrome (FMS) tropisetron reduced not only pain perception but also had a favourable effect on cardiac dysfunction during treatment.
storage
Room temperature (desiccate)
Properties of Tropisetron hydrochloride
| Melting point: | 283-285°C |
| RTECS | NL6012520 |
| storage temp. | 2-8°C |
| solubility | H2O: >10mg/mL |
| form | solid |
| color | White to Light yellow |
| Water Solubility | Soluble in water |
| Merck | 14,9783 |
| InChI | InChI=1/C17H20N2O2.ClH/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;/h2-5,10-13,15H,6-9H2,1H3;1H/t11-,12+,13?,15?; |
| CAS DataBase Reference | 105826-92-4(CAS DataBase Reference) |
Safety information for Tropisetron hydrochloride
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P321:Specific treatment (see … on this label). P405:Store locked up. |
Computed Descriptors for Tropisetron hydrochloride
| InChIKey | ZAOQBEAHJFSJLY-NBVCILBMNA-N |
| SMILES | C12C=CC=CC=1N=CC2C(=O)OC1C[C@]2([H])N(C)[C@@]([H])(CC2)C1.Cl |&1:14,18,r| |
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