Tris(dibenzylideneacetone)dipalladium-chloroform adduct

Chemical properties

purple to black crystalline powder

The Uses of Tris(dibenzylideneacetone)dipalladium-chloroform adduct

suzuki reaction

The Uses of Tris(dibenzylideneacetone)dipalladium-chloroform adduct

Tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct is a catalyst that is used in the preparation of anticancer activity of amino vinylindoles via palladium catalyzed coupling of hydrazone, haloindoles and amines.

What are the applications of Application

Tris DBA chloroform adduct is an NMT1 inhibitor with antiproliferative properties

What are the applications of Application

Tris(dibenzylideneacetone)dipalladium-chloroform adduct (Pd2dba3·CHCl3) was used in the following studies:
To compose the catalytic system for the preparation of homoallylpalladium complexes.These complexes underwent in situ Stille type cross coupling with various vinyltin reagents to afford the cyclized products bearing allyl appendages.
As palladium source in the asymmetric transformations of 3,4-epoxy-1-butene.
As catalyst for the Heck cross-coupling reaction of iodobenzene with styrene.
As cyclization catalyst.
As catalyst for [2+2+2] cycloaddtion of didehydrotriphenylenes to the corresponding extended triphenylenes.
As catalyst for the carbonylation of b,b-imidoyl iodides to the corresponding imidate esters used, in turn, to prepare cyclic, quaternary amino acids.

General Description

Tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct (Pd₂dba₃·CHCl₃) is reported to serve as effective precatalysts, or precursors to the active Pd(0) catalyst.

Biological Activity

N -myristoyltransferase-1 (NMT-1) inhibitor that prevents activation of MAPK, PI 3-K and STAT3 signaling pathways. Exhibits antiproliferative activity against melanoma cells in vitro and in vivo . Also used as a cyclization catalyst.