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HomeProduct name listTris(4-methoxyphenyl)phosphine

Tris(4-methoxyphenyl)phosphine

  • CAS NO.:855-38-9
  • Empirical Formula: C21H21O3P
  • Molecular Weight: 352.36
  • MDL number: MFCD00014896
  • EINECS: 212-723-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:15:32
Tris(4-methoxyphenyl)phosphine Structural

What is Tris(4-methoxyphenyl)phosphine?

Chemical properties

White to pale yellow crystalline powder

The Uses of Tris(4-methoxyphenyl)phosphine

Tris(4-methoxyphenyl)phosphine is a useful intermediate employed in organic synthesis and in other chemical processes.

The Uses of Tris(4-methoxyphenyl)phosphine

suzuki reaction

What are the applications of Application

Tris(4-methoxyphenyl)phosphine is used as a ligand in organometallic chemistry and homogeneous catalysis.
This compound is suitable for the following reaction types: Buchwald-Hartwig Cross Coupling Reaction, Heck Reaction, Hiyama Coupling, Negishi Coupling, Sonogashira Coupling, Stille Coupling, Suzuki-Miyaura Coupling, and Cross Couplings.

Synthesis

To a solution of tertiary phosphine oxides 2 (0.4mmol) in CH2Cl2 (2mL) was added oxalyl chloride (0.4mmol) dropwise at room temperature under an argon atmosphere. After 30 minutes, HEH (1mmol) was added to the mixture in one portion, and TEA (3mmol) was added. The mixture was stirred for another 2h at 40°C and then diluted with H2O (10mL). The resulting mixture was extracted with CH2Cl2 repeatedly. The extracts were dried (anhydrous Na2SO4) and evaporated. The crude product was purified by column chromatography on silica gel using ethyl acetate/petroleum ether to afford the pure product Tris(4-methoxyphenyl)phosphine.

Properties of Tris(4-methoxyphenyl)phosphine

Melting point: 131-134 °C (lit.)
Boiling point: 457.8±40.0 °C(Predicted)
Density  1.1352 (estimate)
storage temp.  Inert atmosphere,Room Temperature
form  Crystalline Powder
color  White to pale yellow
Water Solubility  Insoluble in water.
Sensitive  Air Sensitive
BRN  2815911
InChI InChI=1S/C21H21O3P/c1-22-16-4-10-19(11-5-16)25(20-12-6-17(23-2)7-13-20)21-14-8-18(24-3)9-15-21/h4-15H,1-3H3
CAS DataBase Reference 855-38-9(CAS DataBase Reference)
EPA Substance Registry System Phosphine, tris(4-methoxyphenyl)- (855-38-9)

Safety information for Tris(4-methoxyphenyl)phosphine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Tris(4-methoxyphenyl)phosphine

InChIKey UYUUAUOYLFIRJG-UHFFFAOYSA-N
SMILES P(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=C(OC)C=C1

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