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HomeProduct name listTriphenylethylene

Triphenylethylene

  • CAS NO.:58-72-0
  • Empirical Formula: C20H16
  • Molecular Weight: 256.34
  • MDL number: MFCD00004765
  • EINECS: 200-395-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:08:52
Triphenylethylene Structural

What is Triphenylethylene?

Chemical properties

White to slightly beige powder

The Uses of Triphenylethylene

Triphenylethylene is used in preparation of Esterase activated aggregation-induced luminescent anticancer prodrug.

Definition

ChEBI: Triphenylethylene is a stilbenoid. It is the core chemical structure of a number of related anti-estrogen compounds. The triphenylethylene antiestrogens, which include idoxifene, toremifene, chlorotrianisene, raloxifene and tamoxifen, act at the level of the estrogen receptor, triggering inhibition or stimulation of estrogen-dependent gene transcription and cellular physiology.

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 82, 1956 DOI: 10.1021/ja01582a025
Organic Syntheses, Coll. Vol. 2, p. 606, 1943
Tetrahedron Letters, 14, p. 4193, 1973

Safety Profile

Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Properties of Triphenylethylene

Melting point: 69-71 °C (lit.)
Boiling point: 219-221°C 14mm
Density  1.0373
refractive index  1.6292
Flash point: 219-221°C/14mm
storage temp.  Store below +30°C.
color  White
BRN  1867462
CAS DataBase Reference 58-72-0(CAS DataBase Reference)
NIST Chemistry Reference Benzene, 1,1',1''-(1-ethenyl-2-ylidene)tris-(58-72-0)
EPA Substance Registry System Triphenylethylene (58-72-0)

Safety information for Triphenylethylene

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Environment
GHS09
GHS Hazard Statements H302:Acute toxicity,oral
H319:Serious eye damage/eye irritation
H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P273:Avoid release to the environment.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501:Dispose of contents/container to..…

Computed Descriptors for Triphenylethylene

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