Triphenylethylene

CAS NO.：58-72-0
Empirical Formula: C20H16
Molecular Weight: 256.34
MDL number: MFCD00004765
EINECS: 200-395-1
SAFETY DATA SHEET (SDS)
Update Date: 2023-12-25 13:23:17

What is Triphenylethylene?

Chemical properties

White to slightly beige powder

The Uses of Triphenylethylene

Triphenylethylene is used in preparation of Esterase activated aggregation-induced luminescent anticancer prodrug.

Definition

ChEBI: Triphenylethylene is a stilbenoid. It is the core chemical structure of a number of related anti-estrogen compounds. The triphenylethylene antiestrogens, which include idoxifene, toremifene, chlorotrianisene, raloxifene and tamoxifen, act at the level of the estrogen receptor, triggering inhibition or stimulation of estrogen-dependent gene transcription and cellular physiology.

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 82, 1956 DOI: 10.1021/ja01582a025
Organic Syntheses, Coll. Vol. 2, p. 606, 1943
Tetrahedron Letters, 14, p. 4193, 1973

Safety Profile

Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Properties of Triphenylethylene

Melting point:	69-71 °C (lit.)
Boiling point:	219-221°C 14mm
Density	1.0373
refractive index	1.6292
Flash point:	219-221°C/14mm
storage temp.	Store below +30°C.
color	White
BRN	1867462
CAS DataBase Reference	58-72-0(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1,1',1''-(1-ethenyl-2-ylidene)tris-(58-72-0)
EPA Substance Registry System	Triphenylethylene (58-72-0)

Safety information for Triphenylethylene

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H319:Serious eye damage/eye irritation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P501:Dispose of contents/container to..…