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HomeProduct name listTriphenylacetic acid

Triphenylacetic acid

Synonym(s):Tritylformic acid

  • CAS NO.:595-91-5
  • Empirical Formula: C20H16O2
  • Molecular Weight: 288.35
  • MDL number: MFCD00004185
  • EINECS: 209-873-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-06-12 11:13:47
Triphenylacetic acid Structural

What is Triphenylacetic acid?

Chemical properties

white to beige fine crystalline powder

The Uses of Triphenylacetic acid

2,2,2-Triphenylacetic Acid is used in preparation of Rhodium(II) Tetramethyl-benzenedipropioate complex, other Carboxylate complexes, and their catalytic activity.

What are the applications of Application

Triphenylacetic acid could be used to seal dye molecules within MOF-5. Introducing triphenylacetic acid (TPAA) capping groups traps organic dyes such as crystal violet (CV) within the MOF crystals. Surface-bound TPAA groups block the MOF pores, preventing the encapsulated dye from diffusing into the solution. Liberating the TPAA from the surface by protonation can reverse guest trapping, but acidic conditions can also degrade the MOF by extruding the carboxylate struts. In addition, triphenylacetic acid could inhibit microsomal bilirubin UDPglucuronosyltransferase activity in rat liver. This compound competitively inhibits bilirubin UDP-glucuronosyltransferase with respect to bilirubin[2-3].

Synthesis Reference(s)

The Journal of Organic Chemistry, 28, p. 1725, 1963 DOI: 10.1021/jo01041a520

Reactivity Profile

Triphenylacetic acid can be selectively fluorinated in dimethylsulfoxide/ HgF2 solutions under UV-visible illumination[1].

References

[1] Habibi, Mohammed H., and T. E. Mallouk. "Photochemical selective fluorination of organic molecules using mercury (II) fluoride." Journal of Fluorine Chemistry 51.2(1991):291-294.
[2] Yan, J. , et al. "On-demand guest release from MOF-5 sealed with nitrophenylacetic acid photocapping groups. " Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 18.12(2019):2849-2853.
[3] Fournel, S, et al. "Inhibition of bilirubin UDPglucuronosyltransferase activity by triphenylacetic acid and related compounds. " BBA - General Subjects 883.2(1986):190-196.

Properties of Triphenylacetic acid

Melting point: 270-273 °C (lit.)
Boiling point: 390.57°C (rough estimate)
Density  1.0992 (rough estimate)
refractive index  1.7580 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  DMSO (Slightly), Methanol (Slightly)
form  Fine Crystalline Powder
pka pK1:3.96 (25°C)
color  White to beige
InChI InChI=1S/C20H16O2/c21-19(22)20(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H,(H,21,22)
CAS DataBase Reference 595-91-5(CAS DataBase Reference)
NIST Chemistry Reference Triphenylacetic acid(595-91-5)

Safety information for Triphenylacetic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Triphenylacetic acid

InChIKey DCYGAPKNVCQNOE-UHFFFAOYSA-N
SMILES C(C1C=CC=CC=1)(C1C=CC=CC=1)(C1C=CC=CC=1)C(=O)O

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