TRIPELENNAMINE HYDROCHLORIDE
- CAS NO.:154-69-8
- Empirical Formula: C16H22ClN3
- Molecular Weight: 291.82
- MDL number: MFCD00012815
- EINECS: 205-833-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:15
What is TRIPELENNAMINE HYDROCHLORIDE?
Chemical properties
White Solid
The Uses of TRIPELENNAMINE HYDROCHLORIDE
Tripelennamine is a first-generation antihistamine, used in the treatment of asthma, hay fever, and urticaria.
The Uses of TRIPELENNAMINE HYDROCHLORIDE
antihistaminic;histamine H1 antagonist
brand name
PBZ (Novartis).
General Description
Odorless white crystalline powder or solid. Bitter taste. Solutions are neutral to litmus. pH of aqueous solution (25 mg/mL): 6.71. pH of aqueous solution (50 mg/mL): 6.67. pH of aqueous solution (100 mg/mL): 5.56.
General Description
Tripelennamine hydrochlorideis a white crystalline powder that darkensslowly on exposure to light. The salt is soluble in water(1:0.77) and in alcohol (1:6). It has a pKa of about 9, and a0.1% solution has a pH of about 5.5.
Tripelennamine, the first ethylenediamine developed inthe United States and is well absorbed when given orally. Itappears to be as effective as diphenhydramine and may havethe advantage of fewer and less severe side reactions.Drowsiness may occur, however, and may impair the abilityto perform tasks requiring alertness. The concurrent use ofalcoholic beverages should be avoided.
Air & Water Reactions
Water soluble.
Reactivity Profile
TRIPELENNAMINE HYDROCHLORIDE behaves as a weak organic acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
Fire Hazard
Flash point data for TRIPELENNAMINE HYDROCHLORIDE are not available; however, TRIPELENNAMINE HYDROCHLORIDE is probably combustible.
Veterinary Drugs and Treatments
Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects. Tripelennamine has been used as a CNS stimulant in “Downer cows” when administered slow IV.
Properties of TRIPELENNAMINE HYDROCHLORIDE
Melting point: | 192-193℃ |
Density | 1.20 |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | DMSO : 25 mg/mL (85.67 mM; Need ultrasonic) |
form | neat |
form | Solid |
color | White to off-white |
EPA Substance Registry System | Tripelennamine hydrochloride (154-69-8) |
Safety information for TRIPELENNAMINE HYDROCHLORIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for TRIPELENNAMINE HYDROCHLORIDE
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