Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listTriMethyl(broModifluoroMethyl)silane

TriMethyl(broModifluoroMethyl)silane

  • CAS NO.:115262-01-6
  • Empirical Formula: C4H9BrF2Si
  • Molecular Weight: 203.1
  • MDL number: MFCD18641931
  • EINECS: 806-938-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-04-15 18:41:30
TriMethyl(broModifluoroMethyl)silane Structural

What is TriMethyl(broModifluoroMethyl)silane?

Chemical properties

Colorless transparent liquid, initial boiling point 108℃, relative density 1.31 g/cm3.

The Uses of TriMethyl(broModifluoroMethyl)silane

Trimethyl(bromodifluoromethyl)silane can be used as neuroactive steroids.

The Uses of TriMethyl(broModifluoroMethyl)silane

Novel difluorocarbene source for the efficient difluoromethylenation of alkenes/alkynes and difluoromethylation of O-, S-, and N-nucleophiles.

The Uses of TriMethyl(broModifluoroMethyl)silane

As reported by Hu and co-workers, (Bromodifluoromethyl)trimethylsilane is a highly useful reagent for the formation of difluoromethene-containing 3-membered rings and can also difluoromethylate heteroatoms with the assistance of alkaline bases, most effectively KOH.

What are the applications of Application

  • TriMethyl(broModifluoroMethyl)silane commonly can be used as a source for generating difluorocarbene, it is a general reagent with broad synthetic utility.
  • Can generate difluorocarbene under neutral/acidic/basic conditions in the presence/absence of water at low/high temperatures.
  • Can be used to prepare gem-difluorocyclopropan(e)nes, O-, S-, N-, and P-difluoromethylated compounds

Reactions

(1) Difluoromethylenation of TMSCN.
TriMethyl(broModifluoroMethyl)silane
Ref. J. Org. Chem. 2012, 77, 5850?5855.
(2) Difluoromethylenation of benzyl and alkylzinc halides.
TriMethyl(broModifluoroMethyl)silane
Ref. Org. Lett. 2013, 15, 917 – 919.
(3) Fluorination aminocarbonylation of aldehydes
TriMethyl(broModifluoroMethyl)silane
Ref. Angew. Chem. Int. Ed. 2022, e202115467

General Description

(Bromodifluoromethyl)trimethylsilane (TMSCF2Br) is commonly used as a source to generate dilfluorocarbene. TMSCF3 (Ruppert–Prakash reagent) and BBr3 undergoes fast halogen–exchange reaction to form MSCF2Br.

References

[1]Angewandte Chemie International Edition.DOI :10.1002/anie.202283811
[2]The Journal of Organic Chemistry.DOI :10.1021/acs.orglett.2c02899

Properties of TriMethyl(broModifluoroMethyl)silane

Boiling point: 108°C(lit.)
Density  1.306
refractive index  n/D1.407
Flash point: 46℃
storage temp.  -20°C
form  liquid
color  clear
CAS DataBase Reference 115262-01-6

Safety information for TriMethyl(broModifluoroMethyl)silane

Signal word Warning
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H226:Flammable liquids
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for TriMethyl(broModifluoroMethyl)silane

InChIKey WDZVWBWAUSUTTO-UHFFFAOYSA-N

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.