Chloromethyltrimethylsilane

Synonym(s):(Chloromethyl)trimethylsilane;(Trimethylsilyl)methyl chloride;Silane CMM3;Trimethylsilylchloromethane

CAS NO.：2344-80-1
Empirical Formula: C4H11ClSi
Molecular Weight: 122.67
MDL number: MFCD00000878
EINECS: 219-058-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-01 18:09:03

What is Chloromethyltrimethylsilane?

Description

Chloromethyltrimethylsilane is a chemical compound belonging to the trifluoroacetic acid group. It is an essential synthetic intermediate in organic chemistry, used to prepare many types of compounds, including pharmaceuticals, agrochemicals, and dyes. The molecule consists of three silanes linked together by methylene bridges. The synthesis of Chloromethyltrimethylsilane involves reacting a mixture of hydrochloric acid and trifluoroacetic acid with methyl ketones in the presence of ethylene diamine and particles.

Chemical properties

CLEAR COLOURLESS LIQUID

The Uses of Chloromethyltrimethylsilane

(Chloromethyl)trimethylsilane is used for Wittig reaction and building blocks.

The Uses of Chloromethyltrimethylsilane

(Chloromethyl)trimethylsilane can be treated with aldehydes or ketones in the presence of triphenylphosphine to synthesize terminal alkenes. It can also be used in the preparation of a reagent, trimethylsilylmethyl magnesium chloride, commonly used in Peterson methylenation.

Properties of Chloromethyltrimethylsilane

Melting point:	<0°C
Boiling point:	98-99 °C(lit.)
Density	0.88 g/mL at 20 °C
vapor pressure	~25 mm Hg ( 20 °C)
refractive index	n20/D 1.418(lit.)
Flash point:	27 °F
storage temp.	Store below +30°C.
solubility	soluble in Benzene, Methanol
form	Liquid
color	Clear colorless
Specific Gravity	0.879
Water Solubility	insoluble
Sensitive	Moisture Sensitive
Hydrolytic Sensitivity	4: no reaction with water under neutral conditions
BRN	906705
CAS DataBase Reference	2344-80-1(CAS DataBase Reference)
NIST Chemistry Reference	Silane, (chloromethyl)trimethyl-(2344-80-1)
EPA Substance Registry System	Silane, (chloromethyl)trimethyl- (2344-80-1)

Safety information for Chloromethyltrimethylsilane

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.