Trimetazidine dihydrochloride
Synonym(s):Trimetazidine dihydrochloride
- CAS NO.：13171-25-0
- Empirical Formula: C14H24Cl2N2O3
- Molecular Weight: 339.26
- MDL number: MFCD00243086
- EINECS: 236-117-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:13
What is Trimetazidine dihydrochloride ?
Description
Trimetazidine (hydrochloride) (Item No. 18165) is an analytical reference standard that is structurally categorized as a piperazine. It decreases fatty acid β-oxidation by reversibly inhibiting mitochondrial long-chain 3-ketoacyl thiolase (IC50 = 75 nM). This, in turn, stimulates glucose oxidation. In ischemic heart, trimetazidine reduces ischemia/reperfusion injury in clinical trials. Compounds that reduce mitochondrial fatty acid β-oxidation, including trimetazidine, have shown clinical efficacy against chronic stable angina in clinical trials. In part because of its ability to ameliorate testosterone cardiotoxicity, trimetazidine has been classified as a prohibited substance by the World Anti-Doping Agency. This product is intended for research and forensic applications.
Chemical properties
Crystalline Solid
The Uses of Trimetazidine dihydrochloride
1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride or trimetazidine dihydrochloride can be used as a building block to synthesize:
- Phenylpropyl trimetazidine derivatives with potent cerebral vasodilator activity.
- Benzoylguanidine-trimetazidine derivatives for myocardial ischemic-reperfusion activity studies.
The Uses of Trimetazidine dihydrochloride
Coronary vasodilator. Antianginal
The Uses of Trimetazidine dihydrochloride
Antianoxic
What are the applications of Application
Trimetazidine Dihydrochloride is an antianginal and coronary vasodilator
Definition
ChEBI: Trimetazidine hydrochloride is an aromatic amine.
Properties of Trimetazidine dihydrochloride
| Melting point: | 231-235 °C(lit.) |
| storage temp. | Refrigerator |
| solubility | Freely soluble in water, sparingly soluble in alcohol. |
| form | neat |
| form | Solid |
| color | White to Off-White |
| Merck | 14,9705 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 13171-25-0(CAS DataBase Reference) |
Safety information for Trimetazidine dihydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Trimetazidine dihydrochloride
| InChIKey | XIRALXKCBGTYSC-UHFFFAOYSA-N |
Trimetazidine dihydrochloride manufacturer
Technodrugs Intermediates Pvt. Ltd.
1Y
Phone:+91-2226743405
product: Trimetazidine dihydrochloride 98%
Sharon Bio Medicine Ltd
1Y
Phone:+91-9821911142
Whatsapp: +91 9821911142
product: Trimetazidine dihydrochloride 13171-25-0 99%
Rivashaa Agrotech Biopharma Pvt. Ltd.
1Y
Phone:+91-7926462688
product: 13171-25-0 Trimetazidine dihydrochloride 98%
Tivan Sciences Pvt Ltd
1Y
Phone:+91-9081499099
Whatsapp: +91 9081499099
product: Trimetazidine dihydrochloride 99%
Ralington Pharma
1Y
Phone:+91-9687771722
Whatsapp: +91- 9687771722
product: Trimetazidine dihydrochloride 13171-25-0 98%
BDR Pharmaceuticals International Pvt Ltd
1Y
Phone:+917718884418
Whatsapp: +91-7718884418
product: 13171-25-0 Trimetazidine dihydrochloride 98%
New Products
Tert-butyl bis(2-chloroethyl)carbamate (S)-3-Aminobutanenitrile hydrochloride N-Boc-D-alaninol N-BOC-D/L-ALANINOL N-octanoyl benzotriazole 4-Hydrazinobenzoic acid 3,4-Dibenzyloxybenzaldehyde 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) 4-HYDROXY BENZYL ALCOHOL 3-NITRO-2-METHYL ANILINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 4-methoxy-3,5-dinitropyridine 2-(Cyanocyclohexyl)acetic acid 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride tert-butyl 4- (ureidomethyl)benzylcarbamate diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
You may like
-
13171-25-0 98%View Details
13171-25-0 -
TRIMETAZIDINE 99%View Details
13171-25-0 -
13171-25-0 98%View Details
13171-25-0 -
Trimetazidine impurity I-DiHCl 13171-25-0 98%View Details
13171-25-0 -
13171-25-0 Trimetazidine dihydrochloride 98%View Details
13171-25-0 -
Trimetazidine dihydrochloride 98%View Details
13171-25-0 -
Trimetazidine DiHCl 95% CAS 13171-25-0View Details
13171-25-0 -
1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride CAS 13171-25-0View Details
13171-25-0
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.