Trimetazidine dihydrochloride

Description

Trimetazidine (hydrochloride) (Item No. 18165) is an analytical reference standard that is structurally categorized as a piperazine. It decreases fatty acid β-oxidation by reversibly inhibiting mitochondrial long-chain 3-ketoacyl thiolase (IC₅₀ = 75 nM). This, in turn, stimulates glucose oxidation. In ischemic heart, trimetazidine reduces ischemia/reperfusion injury in clinical trials. Compounds that reduce mitochondrial fatty acid β-oxidation, including trimetazidine, have shown clinical efficacy against chronic stable angina in clinical trials. In part because of its ability to ameliorate testosterone cardiotoxicity, trimetazidine has been classified as a prohibited substance by the World Anti-Doping Agency. This product is intended for research and forensic applications.

Chemical properties

Crystalline Solid

The Uses of Trimetazidine dihydrochloride

1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride or trimetazidine dihydrochloride can be used as a building block to synthesize:

• Phenylpropyl trimetazidine derivatives with potent cerebral vasodilator activity.
• Benzoylguanidine-trimetazidine derivatives for myocardial ischemic-reperfusion activity studies.

The Uses of Trimetazidine dihydrochloride

Coronary vasodilator. Antianginal

The Uses of Trimetazidine dihydrochloride

Antianoxic

What are the applications of Application

Trimetazidine Dihydrochloride is an antianginal and coronary vasodilator

Definition

ChEBI: Trimetazidine hydrochloride is an aromatic amine.