Triethylene glycol dimethyl ether
Synonym(s):1,2-Bis(2-methoxyethoxy)ethane;Dimethyltriglycol;NSC 66400;Triglyme
- CAS NO.:112-49-2
- Empirical Formula: C8H18O4
- Molecular Weight: 178.23
- MDL number: MFCD00008504
- EINECS: 203-977-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-25 16:21:11
What is Triethylene glycol dimethyl ether ?
Chemical properties
Water-white liquid; mild ether odor. D 0.9862 (20/20C), refr index 1.4233 (20C), flash p 232F (111C), bp 216.0C (760mmHg), 153.6C (100 mm Hg), fp ?46C. Completely soluble in water and hydrocarbons at 20C. May contain peroxides. Combustible.
The Uses of Triethylene glycol dimethyl ether
Triethylene glycol dimethyl ether is used as a solvent for gases and coupling immiscible liquid. It is also used to prepare perfluoro-triethyleneglycoldimethylether.
The Uses of Triethylene glycol dimethyl ether
Labelled Triglyme. It is used as a solvent.
The Uses of Triethylene glycol dimethyl ether
Triethylene glycol dimethyl ether may be used as an analytical standard for the quantification of the analyte in water samples using in vitro bioassays and chemical screening technique.
Definition
ChEBI: A polyether that consists of dodecane in which the carbon atoms at positions 2, 5, 8 and 11 are replaced by oxygen atoms.
What are the applications of Application
Triethylene glycol dimethyl ether is a member of the glycol ether class of industrial solvents. These solvents are widely used to manufacture protective coatings such as lacquers, metal coatings, baking enamels, phenolic varnishes, epoxy resin coatings, and alkyl resins[1].
Reactivity Profile
TRIETHYLENE GLYCOL DIMETHYL ETHER forms explosive peroxides on prolonged exposure to air. Its decomposition products may be sensitive to shock. The bulk chemical is stable for 2 weeks at temperatures up to 140° F when protected from light. TRIETHYLENE GLYCOL DIMETHYL ETHER is incompatible with strong oxidizers. TRIETHYLENE GLYCOL DIMETHYL ETHER is also incompatible with strong acids. TRIETHYLENE GLYCOL DIMETHYL ETHER may react with peroxides, oxygen, nitric acid and sulfuric acid. .
Flammability and Explosibility
Non flammable
Toxicology
Triethylene glycol dimethyl ether (triEGdiME) is a widely used organic solvent. It is structurally related to several compounds that produce reproductive and developmental toxicity, including teratogenicity in laboratory animals. In the present studies, triEGdiME (0, 75, 125, 175, or 250 mg/kg/day) is administered by gavage in distilled water to timed-pregnant New Zealand white rabbits (15-25 dams/group) during major organogenesis [Gestational Days (gd) 6-19]. In the triEGdiME study, clinical signs of toxicity were minimal, and there was no increased maternal mortality. Maternal body weight and gravid uterine weight were significantly reduced at 250 mg/kg/day, whereas maternal weight gain during treatment was significant. They were depressed at doses of 175 mg/kg/day and above. Prenatal mortality was significantly increased at 250 mg triEGdiME/kg/day. TriEGdiME at doses of 175 and 250 mg/kg/day caused a significant increase in the incidence of malformed fetuses per litter. Malformations noted most frequently in fetuses of normal size included anonychia (missing toenails with no digital abnormalities), abnormally small spleen, and hydronephrosis[1].
Purification Methods
Reflux it with, and distil it from sodium hydride or LiAlH4. [Beilstein 1 IV 2401.]
Properties of Triethylene glycol dimethyl ether
Melting point: | −45 °C(lit.) |
Boiling point: | 216 °C(lit.) |
Density | 0.986 g/mL at 25 °C(lit.) |
vapor density | >4.7 (vs air) |
vapor pressure | 1.2 hPa (20 °C) |
refractive index | n |
Flash point: | 231 °F |
storage temp. | Store below +30°C. |
solubility | >1000g/l soluble |
form | Liquid |
color | APHA: ≤20 |
explosive limit | 0.7%(V) |
Water Solubility | Soluble |
Sensitive | Hygroscopic |
Merck | 14,9692 |
BRN | 1700630 |
Dielectric constant | 7.5 |
CAS DataBase Reference | 112-49-2(CAS DataBase Reference) |
NIST Chemistry Reference | 2,5,8,11-Tetraoxadodecane(112-49-2) |
EPA Substance Registry System | Triethylene glycol dimethyl ether (112-49-2) |
Safety information for Triethylene glycol dimethyl ether
Signal word | Danger |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Triethylene glycol dimethyl ether
InChIKey | YFNKIDBQEZZDLK-UHFFFAOYSA-N |
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