Tri(Ethylene Glycol) DI-P-Toluenesulfonate
Synonym(s):2,2′-(Ethylenedioxy)diethyl ditosylate;Triethylene glycol ditosylate
- CAS NO.:19249-03-7
- Empirical Formula: C20H26O8S2
- Molecular Weight: 458.55
- MDL number: MFCD00048096
- EINECS: 628-844-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-27 16:40:14
What is Tri(Ethylene Glycol) DI-P-Toluenesulfonate?
Description
Tos-PEG4-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
Chemical properties
WHITE POWDER
The Uses of Tri(Ethylene Glycol) DI-P-Toluenesulfonate
Tri(ethylene glycol) di-p-toluenesulfonate is used in the synthesis of 1-[4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl] ethanone.
Synthesis
2,2'-[1,2-ethanediylbis(oxy)]bisethanol and p-toluenesulfonyl chloride can be used as raw materials for the synthesis of Tri(Ethylene Glycol) DI-P-Toluenesulfonate.
Properties of Tri(Ethylene Glycol) DI-P-Toluenesulfonate
Melting point: | 78-82 °C(lit.) |
Boiling point: | 534.03°C (rough estimate) |
Density | 1.3164 (rough estimate) |
refractive index | 1.6000 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Soluble in ethanol. |
form | powder to crystal |
color | White to Almost white |
BRN | 632509 |
InChI | InChI=1S/C20H26O8S2/c1-17-3-7-19(8-4-17)29(21,22)27-15-13-25-11-12-26-14-16-28-30(23,24)20-9-5-18(2)6-10-20/h3-10H,11-16H2,1-2H3 |
CAS DataBase Reference | 19249-03-7(CAS DataBase Reference) |
EPA Substance Registry System | Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, bis(4-methylbenzenesulfonate) (19249-03-7) |
Safety information for Tri(Ethylene Glycol) DI-P-Toluenesulfonate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Tri(Ethylene Glycol) DI-P-Toluenesulfonate
InChIKey | KCONMNWPRXAWKK-UHFFFAOYSA-N |
SMILES | C(OCCOS(C1=CC=C(C)C=C1)(=O)=O)COCCOS(C1=CC=C(C)C=C1)(=O)=O |
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