neopentyl glycol
Synonym(s):Neopentylglycol;NPG Glycol
- CAS NO.:126-30-7
- Empirical Formula: C5H12O2
- Molecular Weight: 104.15
- MDL number: MFCD00004685
- EINECS: 204-781-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:57
What is neopentyl glycol?
Chemical properties
white solid
The Uses of neopentyl glycol
2,2-Dimethyl-1,3-propanediol may be used in the synthesis of:
- 2,2-dimethyl-1,3-propanediol cyclic phosphorochloridate
- 2,2-dimethyl-1,3-propanediol cyclic phenylphosphonate
- [1′,3′-(2′,2′-dimethylpropylene)]-2-iodo-3-octyl-5-thienylboronate
- cyclic carbonate
- 2,2-dimethyl-1,3-propanediol bis(cyclic-2,2-dimethyltrimethylene phosphite)
The Uses of neopentyl glycol
NPG Glycol is used in the synthesis of tetraphenylporphyrins. Also used in the synthesis of Bryostatin 2, a protein kinase modulator.
The Uses of neopentyl glycol
In the manufacture of plasticizers, polyesters, as modifier of alkyd resins.
Definition
ChEBI: Neopentyl glycol is a propane-1,3-diol carrying two methyl groups at position 2.
Preparation
3-hydroxy-2,2-dimethylpropanal) could be reduced to neopentyl glyco. Hydroxypivaldehyde can be reduced either by a crossed Cannizzaro reaction with equimolar amounts of formaldehyde and a base, or by catalytic hydrogenation. If inorganic bases such as potassium carbonate or sodium hydroxide are used as catalysts, satisfactory yields (ca. 80 %) of neopentyl glycol can be obtained only with an excess of isobutyraldehyde. Tertiary amines are also used as catalysts for the aldol addition. Catalytic transfer hydrogenation of the aldol intermediate is also possible using formate salts as hydrogen source. After fractional distillation a very good yield of high-purity neopentyl glycol is obtained.
General Description
White crystalline solid. Melting point 130°C.
Air & Water Reactions
Soluble in water.
Reactivity Profile
2,2-Dimethyl-1,3-propanediol may generate toxic gases in combination of with alkali metals, nitrides, and strong reducing agents. Reacts with inorganic acids and carboxylic acids to form esters plus water. Converted to aldehydes or acids by oxidizing agents. May initiate the polymerization of isocyanates and epoxides.
In addition to the reactions typical of primary alcohols, such as ester, ether, and carbamate (urethane) formation, 1,3-diols give six-membered cyclic derivatives with carbonyl compounds, carbonates, phosphites, sulfifites, and borates.
Health Hazard
May be harmful by ingestion or skin absorption. Causes eye and skin irritation. Material is irritating to mucous membrane and upper respiratory tract. INHALATION: Call for medical aid. Remove to fresh air. If breathing has stopped, give artificial respiration. If breathing is difficult, give oxygen.
Fire Hazard
Special Hazards of Combustion Products: Emits toxic fumes under fire condition.
Flammability and Explosibility
Non flammable
Solubility in water
Neopentyl glycol is soluble in water, alcohols, and ketones, moderately soluble in hot aromatic solvents, such as benzene and toluene, and relatively insoluble in aliphatic and cycloaliphatic solvents.
storage
During storage, higher temperatures and stacking pressures can lead to caking of the lower stack layers. As a hygroscopic material, 2,2-Dimethyl-1,3-propanediol must be stored dry. The product is also sold as 90 % aqueous solution, which should be stored at 55 – 60 ℃ to avoid precipitation, and as a 100 % melt.
Purification Methods
Crystallise the diol from *benzene or acetone/water (1:1). [Beilstein 1 IV 2551.]
Properties of neopentyl glycol
Melting point: | 126-128 °C |
Boiling point: | 208 °C |
Density | 1.06 |
vapor density | 3.6 (vs air) |
vapor pressure | <0.8 mm Hg ( 20 °C) |
refractive index | 1.4406 (estimate) |
Flash point: | 107 °C |
storage temp. | Inert atmosphere,Room Temperature |
solubility | 830g/l |
form | Crystalline Chunks |
pka | 14.57±0.10(Predicted) |
color | White |
explosive limit | 1.34%, 149°F |
Water Solubility | 830 g/L (20 ºC) |
Sensitive | Hygroscopic |
Merck | 14,6458 |
BRN | 605291 |
Stability: | Stable. Incompatible with strong oxidizing agents, acetic anhydride, acid chlorides, moisture. Combustible. |
CAS DataBase Reference | 126-30-7(CAS DataBase Reference) |
NIST Chemistry Reference | 1,3-Propanediol, 2,2-dimethyl-(126-30-7) |
EPA Substance Registry System | Neopentyl glycol (126-30-7) |
Safety information for neopentyl glycol
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H318:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for neopentyl glycol
neopentyl glycol manufacturer
AKASH PHARMA EXPORTS
Anand Agencies
Oswal Udhyog
M. J. Chemicals
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