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HomeProduct name listTRIETHANOLAMINE SALICYLATE

TRIETHANOLAMINE SALICYLATE

Synonym(s):TEA salicylate;Triethanolamine salicylate;Triethanolaminium salicylate;Tris(2-hydroxyethyl)ammonium 2-hydroxybenzoate

  • CAS NO.:2174-16-5
  • Empirical Formula: C13H21NO6
  • Molecular Weight: 287.31
  • MDL number: MFCD00082325
  • EINECS: 218-531-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:15:30
TRIETHANOLAMINE SALICYLATE Structural

What is TRIETHANOLAMINE SALICYLATE?

Absorption

Following topical administration of 10% trolamine salicylate in healthy volunteers, salicylic acid could not be detected in serum indicating low systemic absorption .

Toxicity

It is hazardous in case of ingestion . The carcinogenicity, mutagenicity and effects on reproductive fertility of trolamine salicylate have not been reported.

Chemical properties

pale yellow to amber crystalline solid

The Uses of TRIETHANOLAMINE SALICYLATE

TriethanolaMine salicylate can be used as intermediate in the manufacture of surface active agents, textile specialties, waxes, polishes, herbicides, petroleum demulsifiers, toilet goods, cement additives, cutting oils. In making emulsions with mineral and vegetable oils, paraffin and waxes. Solvent for casein, shellac, dyes; manufacture of synthetic resins; increasing the penetration of organic liquids into wood and paper. In the production of lubricants for the textile industry. Pharmaceutic aid (alkalizer).

The Uses of TRIETHANOLAMINE SALICYLATE

TEA-salicylate is a chemical uVB absorber. This is one of the 21 FDAapproved sunscreen chemicals with an approved usage level of 5 to 12 percent. TeA-salicylate is a water-soluble chemical with limited uV absorption capability. Formulators may also use it as a preservative.

Background

Trolamine salicylate is an organic compound or a salt formed between triethanolamine and salicylic acid. Triethanolamine neutralizes the acidity of the salicylic acid. It is a topical analgesic used for temporary relief of minor pain associated with arthritis, simple backache, muscle strains, sprains, and bruises. Unlike other topical analgesics, trolamine salicylate has no distinct odor which improves patient acceptability . It also displays low systemic absorption upon dermal or topical administration and has low skin irritant properties . As with other salicylates, trolamine salicylate is an inhibitor of cyclo-oxygenase (COX) enzymes with no reported selectivity towards a specific enzyme isoform. Trolamine salicylate serves as an active ingredient in topical over-the-counter products for temporary management of mild to moderate muscular and joint pains.

Indications

Indicated for the temporary relief of aches, and pains of muscles and joints associated with backache, lumbago, strains, bruises, sprains and arthritic or rheumatic pain, pain of tendons and ligaments .

Pharmacokinetics

Trolamine salicylate is a salicylate that inhibits cyclo-oxygenase (COX) enzymes responsible for generating pro-inflammatory factors such as to induce pain and inflammation. It is thought to mediate its analgesic effect through inhibition of COX-2 enzyme, which is an induced enzyme responsible for inflammatory responses and pain in muscle and joint disorders. By inhibiting fatty acid COX enzyme, trolamine salicylate inhibits the production of prostaglandins and thromboxanes in inflammatory cells involved in generating pain and inflammation . It thereby works to temporarily reduce mild to moderate pain. In subjects with muscle soreness from exercise, administration of topical trolamine salicylate was associated with reduced duration and severity of muscule soreness compared to placebo . In subjects with osteoarthritis in hands, trolamine salicylate cream was shown to be effective in achieving temporary relief of minor pain and stiffness .

Metabolism

Not Available

Properties of TRIETHANOLAMINE SALICYLATE

Density  1.209 g/mL at 25 °C
refractive index  n20/D 1.509
Flash point: 113 °C
form  neat
Odor dull pleasent sweet
BRN  7451205
CAS DataBase Reference 2174-16-5(CAS DataBase Reference)
EPA Substance Registry System Benzoic acid, 2-hydroxy-, compd. with 2,2',2''-nitrilotris[ethanol] (1:1) (2174-16-5)

Safety information for TRIETHANOLAMINE SALICYLATE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for TRIETHANOLAMINE SALICYLATE

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