Triamcinolone acetonide 21-acetate
- CAS NO.:3870-07-3
- Empirical Formula: C26H33FO7
- Molecular Weight: 476.54
- MDL number: MFCD09954497
- EINECS: 223-388-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is Triamcinolone acetonide 21-acetate?
Chemical properties
White Solid
The IUPAC of Triamcinolone acetonide 21-acetate is (11β,16α)-21-(Acetyloxy)-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione.
The Uses of Triamcinolone acetonide 21-acetate
Triamcinolone acetonide 21-acetate is derivative of Triamcinolone Acetonide, a glucocorticoid, antiasthmatic (inhalant).It also can be used for eczema and dermatitis and is currently a long-acting glucocorticoid drug widely applied in the dermatology clinical application of China.
Biological Functions
Triamcinolone acetonide 21-acetate this product is an adrenal cortex hormone drug. There the multiple pharmacological effects such as antiinflammatory, antiallergic, and Immunosuppression. (1) antiinflammatory action: glucocorticoid alleviates and prevents tissue from the reaction of inflammation, thus the performance reduces inflammation. (2) immunosuppressive action: prevent or the immunoreaction of T suppression cell intermediary, the anaphylaxis of retardance, and alleviate and formerly send out expansion immunoreactive. (3) antitoxin, Antishock function: glucocorticoid to the irritant reaction of Nnti-Bacterial endotoxin to the body, can alleviate cell injury, plays the effect of protection body.
Mode of action
Triamcinolone acetonide is a glucocorticoid anti-inflammatory drug. Anti-inflammatory effects are complex, but they are primarily via inhibition of inflammatory cells and suppression of expression of inflammatory mediators. Some older references indicate that triamcinolone (not triamcinolone acetonide) has potency that is approximately equal to methylprednisolone (about 5 times cortisol and 1.25 times prednisolone). However, triamcinolone acetonide, has a different structure than triamcinolone, and is much more potent. This potency is 6–7 times that of prednisolone and slightly more potent than dexamethasone. Most veterinary dermatologists have observed that triamcinolone acetonide is approximately 6–10 times more potent than prednisolone.
Properties of Triamcinolone acetonide 21-acetate
Melting point: | 266 °C |
Boiling point: | 589.4±50.0 °C(Predicted) |
Density | 1.31±0.1 g/cm3(Predicted) |
storage temp. | Refrigerator |
solubility | Chloroform (Slightly, Sonicated), Methanol (Slightly) |
form | Solid |
pka | 13.10±0.70(Predicted) |
color | White to Off-White |
CAS DataBase Reference | 3870-07-3 |
Safety information for Triamcinolone acetonide 21-acetate
Computed Descriptors for Triamcinolone acetonide 21-acetate
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