trans/cis Resveratrol-D4
- CAS NO.:1089051-56-8
- Empirical Formula: C14H8D4O3
- Molecular Weight: 232.267927112
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:06
What is trans/cis Resveratrol-D4?
Description
trans-Resveratrol-d4 is intended for use as an internal standard for the quantification of trans-resveratrol by GC- or LC-MS. trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities. It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively), but not COX-2 (EC50s = >100 μM and 85 μM, respectively). trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate (TPA; ; EC50 = 27 μM). trans-Resveratrol (1-25 μmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, <10, 25, 3.3, and 5 μM, respectively) in vitro and/or ex vivo. It prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.
The Uses of trans/cis Resveratrol-D4
Resveratrol-d4 is labelled Resveratrol (R150000) which is a minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression.
What are the applications of Application
trans-Resveratrol-d4 is an internal standard for the quantification of trans-resveratrol
Properties of trans/cis Resveratrol-D4
storage temp. | Store at -20°C |
solubility | DMF: >100 mg/ml,DMSO: >50mg/ml,Ethanol: >50mg/ml,PBS (pH 7.2): <100 μg/ml |
form | Liquid |
color | Colorless to light yellow |
Safety information for trans/cis Resveratrol-D4
Computed Descriptors for trans/cis Resveratrol-D4
New Products
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