3,4',5-TRIMETHOXY-TRANS-STILBENE
Synonym(s):1,3-dimethoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene; Tri-O-methylresveratrol; Trimethoxy-trans-stilbene
- CAS NO.:22255-22-7
- Empirical Formula: C17H18O3
- Molecular Weight: 270.32
- MDL number: MFCD02093500
- EINECS: 694-659-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-04 15:29:52
What is 3,4',5-TRIMETHOXY-TRANS-STILBENE?
Description
trans-trismethoxy Resveratrol is a polyketide synthase-derived stilbene originally isolated from Virola cuspidata that has diverse biological activities. It is cytotoxic to several cancer cell lines, including PC3, KB, HT-29, SW480, and HL-60 cells (IC50s =3.6, 10.2, 16.1, 54, and 2.5 μM, respectively). trans-trismethoxy Resveratrol (15 μM) inhibits TNF-α-induced activation of NF-κB in HEK293T cells in a reporter assay. It inhibits angiogenesis in zebrafish embryos when used at a concentration of 0.1 μM.
Chemical properties
Pale Yellow Oil
The Uses of 3,4',5-TRIMETHOXY-TRANS-STILBENE
A resveratrol analog with a variety of pharmacology action, including anti-cancer properties, anti-allergic activity, estrogenic activity, antiangiogenic activity, and vascular-targeting activity against microtubule-destabilization
The Uses of 3,4',5-TRIMETHOXY-TRANS-STILBENE
A resveratrol analog with a variety of pharmacology action, including inst microtubule-destabilization
The Uses of 3,4',5-TRIMETHOXY-TRANS-STILBENE
Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health. Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity. When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth and pro-apoptotic activities of resveratrol are enhanced.
What are the applications of Application
3,5,4′-Trimethoxystilbene is an antiangiogenic agent that is shown to inhibit endothelial cell proliferation
Properties of 3,4',5-TRIMETHOXY-TRANS-STILBENE
Melting point: | 57°C |
Boiling point: | 423.8±35.0 °C(Predicted) |
Density | 1.104±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,2-8°C |
solubility | DMSO: ≥34mg/mL |
form | powder to crystal |
color | white to tan |
CAS DataBase Reference | 22255-22-7 |
Safety information for 3,4',5-TRIMETHOXY-TRANS-STILBENE
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Environment GHS09 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3,4',5-TRIMETHOXY-TRANS-STILBENE
New Products
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