TRANS-ACONITIC ACID
Synonym(s):trans-Propene-1,2,3-tricarboxylic acid
- CAS NO.:4023-65-8
- Empirical Formula: C6H6O6
- Molecular Weight: 174.11
- MDL number: MFCD00002721
- EINECS: 223-688-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 19:05:58
What is TRANS-ACONITIC ACID?
Chemical properties
WHITE TO OFF-WHITE CRYSTALLINE POWDER
The Uses of TRANS-ACONITIC ACID
It plays an important role as an antimicrobial agent that blocks the transformation of Leishmania donovani amastigotes to prostigotes. trans-Aconitic acid is also used in synthesis of aconitate esters. It may be used for cross-linking polyvinyl alcohol film for preparing composite nanofiltration membranes.
What are the applications of Application
trans-Aconitic acid is an antimicrobial agent that blocks the transformation of Leishmania donovani amastigotes to prostigotes
Definition
ChEBI: The trans-isomer of aconitic acid.
General Description
trans-Aconitic acid is inhibitor of the tricarboxylic acid cycle and was identified in range grasses.
Biochem/physiol Actions
Antimicrobial agent that blocks the transformation of Leishmania donovani amastigotes to prostigotes.
Purification Methods
Purify trans-acid by dissolving it in AcOH (77g/150mL), filtering and cooling. The acid separates (55g) as colourless needles. A further quantity (10g) can be obtained by reducing the volume of the filtrate. The acid is dried in air then in a vacuum desiccator over NaOH. The acid can be recrystallised from Me2CO/CHCl3. The highest melting point is obtained with the very dry acid. A melting point of 209o was obtained on a Dennis bar [Dennis & Shalton J Am Chem Soc 52 3128 1930, Bruce Org Synth Coll Vol II 12 1943]. [Beilstein 2 IV 2405.]
Properties of TRANS-ACONITIC ACID
Melting point: | 190 °C (dec.)(lit.) |
Boiling point: | 225.05°C (rough estimate) |
Density | 0.56 g/cm3 (20℃) |
refractive index | 1.5860 (estimate) |
FEMA | 2010 | ACONITIC ACID |
storage temp. | Store below +30°C. |
solubility | 400g/l |
form | Solid |
pka | 2.8(at 25℃) |
color | White to Off-White |
PH | 3.14(1 mM solution);2.48(10 mM solution);1.92(100 mM solution) |
Odor | at 100.00 %. vegetable musty nut dry toasted |
Water Solubility | Soluble in water at 20°C 400g/L. Slightly soluble in ether. |
BRN | 1725830 |
CAS DataBase Reference | 4023-65-8(CAS DataBase Reference) |
EPA Substance Registry System | 1-Propene-1,2,3-tricarboxylic acid, (1E)- (4023-65-8) |
Safety information for TRANS-ACONITIC ACID
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for TRANS-ACONITIC ACID
Abamectin manufacturer
VGS SYNTHESIS PRIVATE LIMITED
Frolic Pharmachem
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