TRANS-ACONITIC ACID

Synonym(s):trans-Propene-1,2,3-tricarboxylic acid

CAS NO.：4023-65-8
Empirical Formula: C6H6O6
Molecular Weight: 174.11
MDL number: MFCD00002721
EINECS: 223-688-6
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is TRANS-ACONITIC ACID?

Chemical properties

WHITE TO OFF-WHITE CRYSTALLINE POWDER

The Uses of TRANS-ACONITIC ACID

It plays an important role as an antimicrobial agent that blocks the transformation of Leishmania donovani amastigotes to prostigotes. trans-Aconitic acid is also used in synthesis of aconitate esters. It may be used for cross-linking polyvinyl alcohol film for preparing composite nanofiltration membranes.

What are the applications of Application

trans-Aconitic acid is an antimicrobial agent that blocks the transformation of Leishmania donovani amastigotes to prostigotes

Definition

ChEBI: The trans-isomer of aconitic acid.

General Description

trans-Aconitic acid is inhibitor of the tricarboxylic acid cycle and was identified in range grasses.

Biochem/physiol Actions

Antimicrobial agent that blocks the transformation of Leishmania donovani amastigotes to prostigotes.

Purification Methods

Purify trans-acid by dissolving it in AcOH (77g/150mL), filtering and cooling. The acid separates (55g) as colourless needles. A further quantity (10g) can be obtained by reducing the volume of the filtrate. The acid is dried in air then in a vacuum desiccator over NaOH. The acid can be recrystallised from Me2CO/CHCl3. The highest melting point is obtained with the very dry acid. A melting point of 209o was obtained on a Dennis bar [Dennis & Shalton J Am Chem Soc 52 3128 1930, Bruce Org Synth Coll Vol II 12 1943]. [Beilstein 2 IV 2405.]

Properties of TRANS-ACONITIC ACID

Melting point:	190 °C (dec.)(lit.)
Boiling point:	225.05°C (rough estimate)
Density	0.56 g/cm3 (20℃)
refractive index	1.5860 (estimate)
FEMA	2010 \| ACONITIC ACID
storage temp.	Store below +30°C.
solubility	400g/l
form	Solid
pka	2.8(at 25℃)
color	White to Off-White
PH	3.14(1 mM solution);2.48(10 mM solution);1.92(100 mM solution)
Odor	at 100.00 %. vegetable musty nut dry toasted
Water Solubility	Soluble in water at 20°C 400g/L. Slightly soluble in ether.
BRN	1725830
CAS DataBase Reference	4023-65-8(CAS DataBase Reference)
EPA Substance Registry System	1-Propene-1,2,3-tricarboxylic acid, (1E)- (4023-65-8)

Safety information for TRANS-ACONITIC ACID

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.