Tosyl azide

Synonym(s):p-Toluenesulfonazide solution;4-Methylbenzenesulfonyl azide solution;Tosyl azide solution

CAS NO.：941-55-9
Empirical Formula: C7H7N3O2S
Molecular Weight: 197.21
MDL number: MFCD00180767
EINECS: 213-381-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-19 17:35:41

What is Tosyl azide?

Chemical properties

Colorless to slight yellow liquid

The Uses of Tosyl azide

Used for the introduction of azide and diazo functional groups. It is also used as a nitrene source and as a substrate for [3+2] cycloaddition reactions.

The Uses of Tosyl azide

4-Methylbenzenesulfonyl Azide can be used to target Bcl-2 family proteins to potentially treat cancer.

The Uses of Tosyl azide

p-Toluenesulfonyl azide solution can be employed as a reagent along with alkyne, and amine in the three-component coupling reaction for the synthesis of N-sulfonylamidines in presence of copper catalyst.
It can also be used in the synthesis of N-sulfonyl-1,2,3-triazoles by azide-alkyne cycloaddition reaction in the presence of copper catalyst.

Synthesis Reference(s)

Synthetic Communications, 17, p. 1015, 1987 DOI: 10.1080/00397918708063962
Tetrahedron Letters, 28, p. 5091, 1987 DOI: 10.1016/S0040-4039(00)95598-9

Properties of Tosyl azide

Melting point:	22 °C
Density	~0.90 g/mL at 20 °C
refractive index	n20/D 1.548
Flash point:	4℃
storage temp.	2-8°C
EPA Substance Registry System	Benzenesulfonyl azide, 4-methyl- (941-55-9)

Safety information for Tosyl azide

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H225:Flammable liquids H300:Acute toxicity,oral H304:Aspiration hazard H315:Skin corrosion/irritation H336:Specific target organ toxicity,single exposure; Narcotic effects H373:Specific target organ toxicity, repeated exposure H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P273:Avoid release to the environment. P331:Do NOT induce vomiting. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.