Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listTolterodine tartrate

Tolterodine tartrate

Synonym(s):E;s (R)-2-[3-[bis(1-methylethyl)-amino]1-phenylpropyl]-4-methylphenol [R-(R*,R*)]2,3dihydroxybutanedioate (1:1) (salt);(R)-Tolterodine L-tartrate;2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl-phenol tartrate;Detrusitol

  • CAS NO.:124937-52-6
  • Empirical Formula: C26H37NO7
  • Molecular Weight: 475.57
  • MDL number: MFCD07771985
  • EINECS: 620-503-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
Tolterodine tartrate Structural

What is Tolterodine tartrate?

Chemical properties

White-to-Off-White Crystalline Powder

Originator

Detrol,Pharmacia and Upjohn

The Uses of Tolterodine tartrate

Tolterodine tartrate (Detrol LA) is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist. Tolterodine tartrate (Detrol LA) is indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urge

The Uses of Tolterodine tartrate

A muscarinic receptor antagonist. Used in the treatment of urinary incontinence.

The Uses of Tolterodine tartrate

Tolterodine (tartrate) is a competitive antagonist of muscarinic (M) receptors (Ki = 1.4, 2.7, 3.6, 3.1, and 2.2 nM for M1 through M5, respectively). Antagonists of muscarinic receptors, including tolterodine, are effective in treating overactive bladder symptoms.[Cayman Chemical]

Manufacturing Process

Trans-cinnamic acid (100 g, 675 mmol) is added to a 1 L 4-neck round bottom flask equipped with a mechanical stirrer, thermocouple, and nitrogen inlet. Para-cresol (76.6 g, 708 mmol) is preheated in a water bath at 60°C and added to the cinnamic acid followed by concentrated sulfuric acid (13.0 ml, 243 mmol). The reaction is immediately heated to a set point of 122.5°C and stirred at 120°-125°C until judged to be complete by HPLC analysis. When the reaction is complete the mixture is cooled to 100°C and added to a prewarmed separatory funnel (500 ml). The bottom layer containing the sulfuric acid is removed and toluene (280 ml), water (50 ml) and potassium carbonate (47%, 10 ml) are added to the separatory funnel containing the crude product. The pH of the aqueous layer is adjusted to between 5-8 with additional 47% potassium carbonate. The layers are separated and the organic layer is then washed once with water (50 ml). The organic layer is concentrated to a final volume of approximately 150 ml under reduced pressure. Isopropanol (350 ml) is then added, and distillation is continued to a volume of 350 ml. Isopropanol (150 ml) is again added and again distilled to 350 ml (2 times). The mixture is then cooled to 30°-40°C with rapid stirring until the product crystallizes. The rapid stirring is continued after crystallization. The product is cooled to 0°-5°C and held at this temperature for 1 h, filtered and washed with isopropanol (200 ml) cooled to 0°-5°C. If the last portion of the wash is colored the wash is continued until no more color is removed. The solids are then dried at 60°C under reduced pressure to give the 3,4-dihydro-6-methyl-4-phenyl-2H-benzopyran-2-one, melting point (uncorrected) 83°-85°C.
3,4-Dihydro-6-methyl-4-phenyl-2H-benzopyran-2-one (100.0 g, 420.2 mmol) is added to toluene (500 ml). The mixture is degassed by purging alternately with vacuum and nitrogen and then cooled to -21°C. Diisobutylaluminum hydride in toluene solution (DIBAL, 1.5 M, 290 ml, 435 mmol) is then slowly added over 2 h via add funnel while maintaining the reaction temperature at - 20°-25°C. The reaction is usually done when the DIBAL add is completed. If the reaction is not done additional DIBAL can be added in increments. When the reaction is done (<1% lactone) ethyl acetate (45 ml) is added at -20°- 25°C via add funnel. Very little exotherm is observed. Next, citric acid (23%, 500 ml) is added. The mixture is stirred at 45°-50°C for 1 h (or stirred overnight at 20°-25°C), the phases are separated, the organic phase is washed with water (2 times 300 ml). The organic phase is concentrated to 250 ml under reduced pressure. Methanol (500 ml) is added, and the mixture is concentrated to 250 ml. The methanol addition and distillation is repeated to give the 3,4-dihydro-6-methyl-4-phenyl-2H-benzopyran-2-ol in methanol solution.
3,4-Dihydro-6-methyl-4-phenyl-2H-benzopyran-2-ol in methanol (500 ml) is slowly added to palladium on carbon (5%, 22 g, 1.5 mmol) while maintaining a slight nitrogen purge. If 3,4-dihydro-6-methyl-4-phenyl-2H-benzopyran-2-ol is added too quickly without a nitrogen purge the catalyst will ignite the methanol. Diisopropylamine (147.0 ml, 1.05 mol) is added, and the mixture is hydrogenated at 45-50 psi and 48°C until the reaction is judged to be complete by HPLC (<2% lactol). The reaction is usually done after 10 h, but can be run overnight. The reaction mixture is cooled and removed from the hydrogenator using a methanol (150 ml) rinse. The combined reaction mixture and rinse is filtered through a bed of solka floc (10 g). The solka floc is washed thoroughly with methanol (100 ml) and the filtrate is concentrated to remove methanol while ethyl acetate is being added back. The volume of this solution of the (2-diisopropylamino)ethyl)benzyl)-p-cresol is adjusted to 700 ml using ethyl acetate and the mixture is heated to 55°C. To form the hydrochloride salt of the (2-diisopropylamino)ethyl)benzyl)-p_x0002_cresol (Tolterodine), concentrated hydrochloric acid (52.5 ml, 630 mmol) is added over 15 min. The resulting slurry is gradually cooled to -15°-20°C and held at this temperature for 1 h. Tolterodine hydrochloride is collected by filtration, washed 3 times with ethyl acetate, and dried overnight under reduced pressure at 600 to give the tolterodine hydrochloride, melting point 199°-201°C. Tolterodine hydrochloride (130.0 g, 359 mmol), methylene chloride (1.3 L) and water (650 ml) are mixed. The mixture is stirred rapidly while adding sodium hydroxide (50%, 13.0 ml) and sodium carbonate (13.0 g, 123 mmol). The pH as determined by pH paper is 10-11. After stirring thoroughly for approximately 15 min two clear homogeneous phases form. Stirring is continued for another 45 min, the layers are separated and the organic phase is washed with water (2 times 650 ml). The methylene chloride mixture is concentrated under reduced pressure. The concentrate is dissolved in ethanol (325 ml) and warmed to 60°-70°C. L-tartaric acid (80.84 g, 539 mmol) slurried in hot ethanol (810 ml) is added via add funnel at 60°-70°C over approximately 30 min. When the addition is done the slurry is refluxed for 1 h, gradually cooled to 0°C and held at this temperature for 1 h. The slurry is filtered, washed with ethanol (2 times 260 ml) previously cooled to 0°C, and dried overnight under reduced pressure at 60°C to give the crude title compound. The crude product (136.0 g) and ethanol (5.44 L) are mixed and heated to 80°C for 30 min. The mixture is concentrated to half the initial volume by distilling 2.72 L of ethanol. The mixture is gradually cooled to 20°- 25°C over 1 h, placed in an ice bath, and held at 0°C for 1 h. The tolterodine L-tartrate is collected by filtration, washed with ethanol (2 times 272 ml ) previously cooled to 0°C, and dried overnight under reduced pressure at 60°C to give product. This procedure was repeated a second time on 81.0 g of once recrystallized tolterodine L-tartrate to give the optically active (+)-(R)-2-(α- (2-(diisopropylamino)ethyl)benzyl)-p-cresol L-tartrate, melting point (uncorrected)=210°-211°C.

Therapeutic Function

Anticholinergic

General Description

Tolterodine Tartrate is a tertiary muscarinic?antagonist, basically used to manage urinary frequency, urgency, and incontinence in detrusor instability.

Biological Activity

tolterodine tartrate (detrol la) is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist.

Clinical Use

Selective vasopressin V2 -receptor antagonist:
Treatment of hyponatraemia secondary to SIADH
To slow the progression of autosomal dominant polycystic kidney disease (ADPKD)

Drug interactions

Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased risk of ventricular arrhythmias with amiodarone, disopyramide and flecainide; increased risk of antimuscarinic side effects with disopyramide.
Antifungals: avoid concomitant use with itraconazole and ketoconazole.
Antivirals: avoid concomitant use with fosamprenavir, indinavir, lopinavir, ritonavir and saquinavir.
Beta-blockers: increased risk of ventricular arrhythmias with sotalol.

Metabolism

Metabolised mainly by the cytochrome P450 isoenzyme CYP3A4. Eliminated mainly by the faecal route

Properties of Tolterodine tartrate

Melting point: 205-210°C
alpha  54625 +36.0°
storage temp.  Sealed in dry,2-8°C
solubility  Methanol (Sparingly), Water (Slightly)
form  Solid
pka 9.87(at 25℃)
color  White to Off-White
CAS DataBase Reference 124937-52-6(CAS DataBase Reference)

Safety information for Tolterodine tartrate

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
ghs
Environment
GHS09
GHS Hazard Statements H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P391:Collect spillage. Hazardous to the aquatic environment
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for Tolterodine tartrate

Abamectin manufacturer

Lupin Ltd

1Y
Phone:+91-8019896181
Whatsapp: +91 8019896181
product: 124937-52-6 99%
Inquiry

Apotex Pharmachem India Pvt Ltd

1Y
Phone:+91-8022891000
product: 124937-52-6 Tolterodine tartrate 98%
Inquiry

Cipla Ltd

1Y
Phone:+912224826000
product: Tolterodine tartrate 98%
Inquiry

Hetero Drugs Limited

1Y
Phone:+914023704923
product: Tolterodine tartrate 124937-52-6 98%
Inquiry

Macleods Pharmaceuticals Limited

1Y
Phone:+912266762800
product: 124937-52-6 Tolterodine tartrate 98%
Inquiry

Vivimed Labs Ltd

1Y
Phone:+91-4066086608
product: 124937-52-6 98%
Inquiry

Unichem Laboratories Ltd

1Y
Phone:+91-2266888333
product: Tolterodine tartrate 98%
Inquiry

Orchid Pharma Ltd. (Formerly Known as Orchid Chemicals and Pharmaceuticals Ltd.)

1Y
Phone:+91-4428244254
product: Tolterodine tartrate 124937-52-6 99%
Inquiry

HRV Global Life Sciences

1Y
Phone:+91-9820219686
Whatsapp: +91 9820219686
product: 124937-52-6 Tolterodine tartrate 99%
Inquiry

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.