Tin(II) fluoride

Absorption

Tin is retained in the demineralized organic matrix to some extent, diffuses through the phosphorylated non-collagenous proteins in the dentine called phosphophoryn and accumulates in the underlying mineralized tissue.

Toxicity

The oral LD50 value in rats is 360mg/kg and the dermal LD50 value is >2000mg/kg. Repeated or prolonged dermal contact can cause irritant symptoms such as reddening of the skin, blisters, or dermatitis.

Chemical properties

white crystals or powder

Chemical properties

Stannous fluoride is a white crystalline solid with a bitter, salty taste.

The Uses of Tin(II) fluoride

Dental caries prophylactic.

The Uses of Tin(II) fluoride

Stannous fluoride (SnF2) is used as a toothpaste additive to help prevent tooth decay.

The Uses of Tin(II) fluoride

Tin(II) fluoride is used in the prevention of dental caries. It is an active ingredient in toothpastes.

Definition

ChEBI: Stannous fluoride is an inorganic fluoride salt.

Background

Stannous Fluoride, or Tn(II) Fluoride, is a compound commonly used in toothpastes for the prevention of gingivitis, dental infections, cavities, and to relieve dental hypersensitivity. Although similar in function and activity to Sodium Fluoride (NaF), the conventionally added ingredient in toothpastes, stannous fluoride has been shown to be more effective at stopping and reversing dental lesions . It manages and prevents dental caries and gingivitis by promoting enamel mineralization , reducing gingival inflammation and bleeding through its potential broad-spectrum antibiotic effect and modulation of the microbial composition of the dental biofilm . It is an FDA-approved over-the-counter product.

Indications

Indicated for use to relieve dental hypersensitivity, increase enamel production, prevent gingivitis and cavities, and control periodontal infections.

General Description

White crystalline solid. Sinks and mixes with water.

Air & Water Reactions

Water soluble.

Reactivity Profile

Tin(II) fluoride, a strong reducing agent, is incompatible with oxidizers. Avoid contact with acids - HF fumes may be produced [USCG, 1999].

Hazard

Toxic by ingestion, strong irritant to skin and tissue.

Health Hazard

EYES: Severe irritation - corrosive, irreversible. SKIN: Corrosive on abraded skin, no effect on intact skin.

Flammability and Explosibility

Not classified

Pharmacokinetics

Stannous fluoride mediates both bactericidal and bacteriostatic properties and provides an anti-erosive action on tooth enamel.

Safety Profile

Poison by ingestion and intraperitoneal routes. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits toxic fumes of F-. See also TIN COMPOUNDS.

Potential Exposure

Stannous fluoride is used in dental caries (tooth decay); as an ingredient of cavity-preventing toothpastes.

Metabolism

Not Available

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2923 Corrosive solids, toxic, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, 6.1Poisonous material, Technical Name Required

Incompatibilities

A strong reducing agent. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Reacts with acids, forming hydrogen fluoride fumes. Reacts violently with chlorine and metal nitrates. Reacts with metals releasing flammable hydrogen gas.