Thalidomide-NH-C4-NH2 TFA
- CAS NO.:2093387-50-7
- Empirical Formula: C19H21F3N4O6
- Molecular Weight: 458.39
- MDL number: MFCD32903491
- Update Date: 2024-04-01 13:48:23
What is Thalidomide-NH-C4-NH2 TFA?
Biological Activity
Thalidomide-NH-C4-NH2 TFA (compound 29c) is an E3 ligase ligand-linker conjugate, and incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-NH-C4-NH2 TFA is used in PROTAC BRD2/BRD4 degrader-1 . PROTAC BRD2/BRD4 degrader-1 is a potent and selective BET protein BRD4 and BRD2 degrader[1].
References
[1]. Jiang F, et al. Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies. Bioorg Med Chem. 2020 Jan 1;28(1):115181.
Safety information for Thalidomide-NH-C4-NH2 TFA
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin G 2,2-diethoxyethanethioamide Tubulysin H Tubulysin A Tubulysin E Imeglimin Hydrochloride IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH 3,3,6,6-Tetramethylcyclohexane-1,2-dione 2-Ethoxy-4-nitrobenzoic acid 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one 2-Chloro-3-(chloromethyl)pyridine (1-Isopropyl-1H-pyrazol-5-yl)boronic acid 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 1,3,5-Trimethyl-1,4-cyclohexadiene 6-bromopyridazin-3-amineRelated products of tetrahydrofuran
-alkylC5-amine
Undecanoic acid, 11-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
Thalidomide-NH-C4-NH-Boc
Thalidomide-NH-PEG2-C2-NH2 (TFA)
Thalidomide-NH-PEG2-C2-NH2 hydrochloride
Thalidomide-NH-C6-NH2 TFA
Thalidomide-C2-amido-C2-COOH
Thalidomide-linker 6
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