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HomeProduct name listThalicarpine

Thalicarpine

Thalicarpine Structural

What is Thalicarpine?

Description

A complex alkaloid, thaliblastine occurs in Thalictrum minus elatum and has been assigned the structure given on the basis of chemical and spectroscopic investigations. The alkaloid has marked antitumour activity but rapid administration of the base causes brachycardia, hypotension and inhibition of respiration in laboratory animals. Slow intravenous injection, however, produces none of these effects. Thaliblastine is cytotoxic to HEF and Sa9 cells in vitro.

Definition

ChEBI: Thalicarpine is a member of isoquinolines and a bisbenzylisoquinoline alkaloid.

References

Todorov, Damyanova,Dokl. Bolg. Akad. Nauk., 28, 709 (1975)

Properties of Thalicarpine

Melting point: 160-161°
Boiling point: 701.43°C (rough estimate)
alpha  D25 +133° (c = 0.83 in methanol); D25 +89° (c = 0.88 in chloroform)
Density  1.1544 (rough estimate)
refractive index  1.4670 (estimate)
pka 7.62±0.40(Predicted)

Safety information for Thalicarpine

Computed Descriptors for Thalicarpine

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