Tetrahydrouridine

Synonym(s):InSolution Tetrahydrouridine - CAS 18771-50-1 - Calbiochem;Tetrahydrouridine - CAS 18771-50-1 - Calbiochem;THU, H4U, 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one, dihydrate

CAS NO.：18771-50-1
Empirical Formula: C9H16N2O6
Molecular Weight: 248.23
MDL number: MFCD00063468
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-18 11:30:59

What is Tetrahydrouridine?

Description

Tetrahydrouridine is a competitive, reversible inhibitor of cytidine deaminase (K_i values = 54 and 240 nM for human and E. coli enzymes, respectively). Its use, alone or in combination with the DNA methyltransferase inhibitor 5-fluoro-2’-deoxycytidine, is being evaluated in animal models and clinical trials for diseases, including cancer and mitochondrial DNA depletion syndrome.

The Uses of Tetrahydrouridine

3,4,5,6-Tetrahydrouridine, is a derivative of Uridine (U829910). Tetrahydrouridine (THU), is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.

What are the applications of Application

Tetrahydrouridine is a CDD inhibitor which may prevent growth of CDA-expressing tumors

Properties of Tetrahydrouridine

Melting point:	>195°C (dec.)
Boiling point:	668.6±55.0 °C(Predicted)
Density	1.622±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	Methanol (Slightly), Water (Slightly)
form	Solid
pka	12.50±0.40(Predicted)
color	White to Off-White
Stability:	Light Sensitive

Safety information for Tetrahydrouridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.