Tetradecylthioacetic acid
Synonym(s):TTA
- CAS NO.:2921-20-2
- Empirical Formula: C16H32O2S
- Molecular Weight: 288.49
- MDL number: MFCD00128230
- EINECS: 1308068-626-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-13 17:03:25
What is Tetradecylthioacetic acid?
Description
Tetradecylthioacetic acid (TTA), a representative member of the 3-thia family, has the chemical structure of palmitic acid (C16) in which a sulfur atom is located between the 2 and 3-carbon atoms (COOH-CH2-S-(CH2)13-CH3). TTA is a novel hypolipidemic drug which has been shown to combine several effects of w-3 PUFAs, such as EPA, and structurally unrelated peroxisome proliferators, such as phenylacetate and fibrates. From this perspective we wanted to investigate if TTA shares the antitumor activity found for these functionally related compounds, and furthermore to study the metabolic effects of TTA in cancer cells in relation to the effects found in hepatocytes.
Chemical properties
White Cyrstalline Solid
The Uses of Tetradecylthioacetic acid
TTA is a novel thio-fatty acid which cannot undergo beta-oxidation. It induces apoptosis in IPC-81 leukemia cells via depolarization of mitochondrial membrane potential and inhibits glioma cell proliferation. TTA completely prevents high fat diet-induce
The Uses of Tetradecylthioacetic acid
TTA is a novel thio-fatty acid which cannot undergo beta-oxidation. It induces apoptosis in IPC-81 leukemia cells via depolarization of mitochondrial membrane potential and inhibits glioma cell proliferation. TTA completely prevents high fat diet-induced insulin resistance and adiposity in Wistar rats. Activates rodent PPAR’s with rank order PPARα>PPARδ>PPARγ.
Definition
ChEBI: 2-(tetradecylthio)acetic acid is a straight-chain fatty acid.
Properties of Tetradecylthioacetic acid
Melting point: | 65-73°C |
Boiling point: | 402.6±28.0 °C(Predicted) |
Density | 0.957±0.06 g/cm3(Predicted) |
RTECS | AJ5087000 |
storage temp. | -20°C Freezer |
solubility | DMSO: ≥22 mg/mL, soluble |
form | Solid |
pka | 3.85±0.10(Predicted) |
color | white |
CAS DataBase Reference | 2921-20-2(CAS DataBase Reference) |
Safety information for Tetradecylthioacetic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Tetradecylthioacetic acid
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