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HomeProduct name listTetradecylthioacetic acid

Tetradecylthioacetic acid

Synonym(s):TTA

  • CAS NO.:2921-20-2
  • Empirical Formula: C16H32O2S
  • Molecular Weight: 288.49
  • MDL number: MFCD00128230
  • EINECS: 1308068-626-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-22 13:59:06
Tetradecylthioacetic acid Structural

What is Tetradecylthioacetic acid?

Description

Tetradecylthioacetic acid (TTA), a representative member of the 3-thia family, has the chemical structure of palmitic acid (C16) in which a sulfur atom is located between the 2 and 3-carbon atoms (COOH-CH2-S-(CH2)13-CH3). TTA is a novel hypolipidemic drug which has been shown to combine several effects of w-3 PUFAs, such as EPA, and structurally unrelated peroxisome proliferators, such as phenylacetate and fibrates. From this perspective we wanted to investigate if TTA shares the antitumor activity found for these functionally related compounds, and furthermore to study the metabolic effects of TTA in cancer cells in relation to the effects found in hepatocytes.

Chemical properties

White Cyrstalline Solid

The Uses of Tetradecylthioacetic acid

TTA is a novel thio-fatty acid which cannot undergo beta-oxidation. It induces apoptosis in IPC-81 leukemia cells via depolarization of mitochondrial membrane potential and inhibits glioma cell proliferation. TTA completely prevents high fat diet-induce

The Uses of Tetradecylthioacetic acid

TTA is a novel thio-fatty acid which cannot undergo beta-oxidation. It induces apoptosis in IPC-81 leukemia cells via depolarization of mitochondrial membrane potential and inhibits glioma cell proliferation. TTA completely prevents high fat diet-induced insulin resistance and adiposity in Wistar rats. Activates rodent PPAR’s with rank order PPARα>PPARδ>PPARγ.

Definition

ChEBI: 2-(tetradecylthio)acetic acid is a straight-chain fatty acid.

Properties of Tetradecylthioacetic acid

Melting point: 65-73°C
Boiling point: 402.6±28.0 °C(Predicted)
Density  0.957±0.06 g/cm3(Predicted)
RTECS  AJ5087000
storage temp.  -20°C Freezer
solubility  DMSO: ≥22 mg/mL, soluble
form  Solid
pka 3.85±0.10(Predicted)
color  white
CAS DataBase Reference 2921-20-2(CAS DataBase Reference)

Safety information for Tetradecylthioacetic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for Tetradecylthioacetic acid

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